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NCT07729540

Overview

NCT ID: NCT07729540
Lead Sponsor: Medical University of SilesiaOTHER
Official Title: Intense Pulsed Light, a Targeted Anti-Redness Dermocosmetic Regimen, and Their Combination for Erythematotelangiectatic Rosacea: A Comparative Study Using Antera 3D Chromophore Mapping, Grey-Level Co-Occurrence Matrix Texture Analysis and Clinician Erythema Assessment Scale.
Brief Summary: This study compares three approaches to treating persistent facial redness in adults with erythematotelangiectatic rosacea: intense pulsed light (IPL) treatment alone, a professional anti-redness dermocosmetic skincare regimen alone, and the combination of both. The main question the study aims to answer is which of these three strategies is more effective at reducing facial redness, using both clinician grading and objective skin-imaging tools that measure redness and skin texture before and after treatment.
Conditions: Rosacea

Status and Timeline

Status: Completed
Last Update Posted: Jul 27, 2026Actual
Start Date: Sep 29, 2025Actual
Primary Completion Date: Apr 30, 2026Actual
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adult patients with a dermatologist-confirmed diagnosis of erythematotelangiectatic rosacea

Exclusion Criteria:

Age under 18 years

Pregnancy or breastfeeding

Predisposition to keloid or hypertrophic scarring

Use of systemic or topical retinoids, antibiotics, or hormonal therapy within the washout period specified for each agent

Chemical peeling within one month

Laser treatment or phototherapy within three months

Photosensitizing medications or herbal preparations

Inflammatory dermatoses other than rosacea

Autoimmune disease

Active skin infection in the treatment area

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 60Actual
Primary Purpose: Treatment
Allocation: Non-Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: No data available
Locations: Medical University of Silesia

Similar Studies

Participant Group/Arms

IPL Monotherapy (Lumecca)Experimental

Three intense pulsed light (IPL) treatments using the Lumecca applicator (InMode; 515-1200 nm) at 21-day intervals. Fluence was individually titrated to skin response and increased across sessions. Broad-spectrum sunscreen SPF 50+ was applied after each session, and daily photoprotection was mandatory.

Device: Intense Pulsed Light (IPL) - Lumecca

Dermocosmetic Regimen (Rosacure Professional)Experimental

Four professional in-office anti-redness treatments using the Rosacure Professional system (Synchroline/Cantabria Labs) at 7-day intervals: gentle cleansing, application of Rosacure Professional Serum Booster (4-t-butylcyclohexanol, niacin amide, panthenol, sodium hyaluronate, polyglutamic acid), and a leave-on regenerating gel mask. Concurrently, a standardized 12-week home-care regimen: twice-daily gentle cleanser, Rosacure Intensive SPF 30 each morning, Rosacure Fast each evening, and a leave-on mask twice weekly.

Other: Rosacure anti-redness dermocosmetic regimen

Combined IPL and Dermocosmetic TherapyExperimental

Three IPL treatments identical to Arm 1 (Lumecca applicator, 515-1200 nm, 21-day intervals), immediately followed within the same session by the professional Rosacure protocol described in Arm 2, together with the same 12-week home-care regimen used in Arm 2.

Device: Intense Pulsed Light (IPL) - Lumecca