Google Maps

NCT07729384

Overview

NCT ID: NCT07729384
Lead Sponsor: Mayo ClinicOTHER
Official Title: Strengthening Teen Brain Resilience Using Music (STRUM) During Cancer Treatment: A Pilot Feasibility Trial
Brief Summary: This clinical trial tests the feasibility and acceptability of the Strengthening Teen Brain Resilience Using Music (STRUM) intervention to improve radiation induced cognitive decline for adolescents undergoing radiation therapy for cancer treatment. Adolescents treated with radiation therapy for cancer often experience persistent cognitive deficits and reduced brain resilience or the ability to preserve cognitive and emotional functioning despite stressors. Musical instrument training has been shown to enhance memory, academic skills, and emotional well-being in youth. Although guitars are often the most preferred instrument, ukuleles offer greater accessibility due to their simplicity, affordability, and suitability for younger users. The STRUM intervention consists of virtual active music therapy ukulele lessons, which may be a feasible and acceptable way to improve radiation induced cognitive decline for adolescents undergoing radiation therapy for cancer treatment.

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 27, 2026Actual
Start Date: Oct 1, 2026Estimated
Primary Completion Date: Nov 1, 2028Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Child (0-17)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Aged 12-17 years at the time of enrollment

Receiving initial radiation therapy (RT) for cancer treatment with curative intent at the Mayo Clinic Arizona

Able to provide assent

Able to read and write in English

Have access to an electronic device with videoconferencing capability

Exclusion Criteria:

Less than three-month prognosis

Past history of RT

Self-reported visual, hearing, or cognitive impairment impeding the ability to complete the STRUM intervention

Prior receipt of ukulele or guitar lessons

Actively receiving musical instrument lessons

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 30Estimated
Primary Purpose: Supportive Care
Allocation: N/A
Interventional Model: Single Group Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Robert Bennett, PhD, RNContact
bennett.robert@mayo.edu480-301-4394

Similar Studies

Participant Group/Arms

Supportive care (STRUM sessions)Experimental

Patients receive a ukulele, tuner, and songbook and attend virtually delivered ukulele lessons over 30 minutes each, once weekly, for 10 weeks. Intervention sessions are structured with stair-stepping difficulty with each lesson concluding with learning a new song. Ten optional supplemental video-recorded lessons (approximately 15 minutes each) will be available for patients to view asynchronously and use for independent practice between weekly sessions. Patients are encouraged to practice their skills independently for at least 90 minutes per week. At the conclusion of the study, patients may attend an optional virtual "Encore Concert Event" remotely, featuring audio-video clips compiled from participants' lessons.

Other: Interview

Procedure: Music Therapy

Other: Survey Administration