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NCT07728123

Overview

NCT ID: NCT07728123
Lead Sponsor: WestatOTHER
Official Title: Screen2Prevent (S2P): Using Digital Health to Improve HIV Screening and Prevention for Adolescents in the Emergency Department
Brief Summary: Screen2Prevent is a study intended to improve HIV prevention and detection through implementation and evaluation of three different broad-scale HIV screening approaches a) targeted, b) universally offered opt-in, and c) universally offered opt-out in Emergency Departments (EDs) by leveraging digital health to identify and link adolescents seeking care in the ED to HIV Pre-Exposure Prophylaxis (PrEP)/Antiretroviral treatment (ART).
Conditions: HIV Infections
Interventions

Status and Timeline

Status: Recruiting
Last Update Posted: Jul 27, 2026Actual
Start Date: Jun 16, 2026Actual
Primary Completion Date: Oct 31, 2028Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Child (0-17)Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Age 14-24 years, inclusive

Present to the participating ED, regardless of chief complaint during the study period

Exclusion Criteria:

None

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 84,000Estimated
Primary Purpose: Screening
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Erin RickettsContact
erinricketts@westat.com240-453-2786

Similar Studies

Participant Group/Arms

1. Universally offered opt-in > Universally offered opt-out > TargetedOther

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Other: HIV screening strategies

2. Universally offered opt-out > Universally offered opt-in > TargetedOther

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Other: HIV screening strategies

3. Universally offered opt-in > Targeted > Universally offered opt-outOther

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Other: HIV screening strategies

4. Universally offered opt-out > Targeted > Universally offered opt-inOther

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Other: HIV screening strategies

5. Targeted > Universally offered opt-out > Universally offered opt-inOther

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Other: HIV screening strategies

6. Targeted > Universally offered opt-in > Universally offered opt-outOther

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months.

Other: HIV screening strategies

Locations

University of South FloridaRecruiting

Tampa, Florida 33612, United States

Elizabeth Enriquez-BruceContact

enriquezbruce@usf.edu813-250-2574

Carina Rodriguez, MDPrincipal Investigator

Emory Atlanta Adolescent ConsortiumNot yet recruiting

Atlanta, Georgia 30322, United States

Johns Hopkins UniversityNot yet recruiting

Baltimore, Maryland 21287, United States

St. Jude Children's Research HospitalRecruiting

Memphis, Tennessee 38015, United States

Baylor College of MedicineNot yet recruiting

Houston, Texas 77030, United States