The goal of this clinical trial is to learn whether short-term treatment with atorvastatin can prevent new abnormal rapid heart rhythms after lung surgery in adults aged 60 years or older who are scheduled to have a lung segment or lung lobe removed. The study will also evaluate the safety of short-term atorvastatin treatment around the time of surgery.
The main questions this study aims to answer are:
Participants will be assigned by chance to receive either short-term atorvastatin treatment or a matching placebo-based comparison treatment. A placebo is a look-alike tablet that does not contain atorvastatin. Participants who were already taking a statin (moderate-intensity) before the study will receive a standardized background statin regimen so that their usual treatment is not stopped unnecessarily. Neither the participants nor most members of the research team will know which treatment has been assigned.
Study treatment will usually begin 2 to 7 days before surgery and continue until 72 hours after surgery. After surgery, participants will wear a portable heart monitor continuously for 72 hours to identify abnormal heart rhythms. Researchers will also collect routine clinical information, blood test results, and safety information during the hospital stay and will follow participants for 30 days after surgery.
Inclusion Criteria:
Exclusion Criteria:
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Participants will receive atorvastatin 40 mg orally once daily, administered as two 20-mg tablets. Treatment will usually begin 2 to 7 days before surgery and continue until 72 hours after surgery.
Statin-naive participants/Participants receiving long-term low-intensity statin therapy will receive two matching placebo tablets orally once daily. Participants receiving long-term moderate-intensity statin therapy before enrollment will receive atorvastatin 20 mg plus one matching placebo tablet once daily. Treatment will usually begin 2 to 7 days before surgery and continue until 72 hours after surgery.
lutaowhiz@sina.com01069152630
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