Evaluation of Enamel Matrix Derivative in Immediate Dental Implants in the Mandibular Molar Region | NCT07727655

NCT07727655

Overview

NCT ID: NCT07727655
Lead Sponsor: Mansoura UniversityOTHER
Official Title: Evaluation of Enamel Matrix Derivative in Management of Jumping Gaps Around Immediate Dental Implants in Mandibular Molar Region. A Randomized Clinical Trial
Brief Summary: This randomized clinical trial will evaluate the effect of using an enamel matrix derivative during immediate dental implant placement in the mandibular molar region. Patients who require extraction of a non-restorable mandibular molar and immediate implant placement will be randomly assigned to receive an implant placed with enamel matrix derivative or without enamel matrix derivative. Clinical and radiographic outcomes, including implant stability and peri-implant bone changes, will be assessed over a follow-up period of six months. The results of this study aim to determine whether the use of enamel matrix derivative improves osseointegration and healing around immediate dental implants.
Conditions: Tooth Loss

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 27, 2026Actual
Start Date: Jun 2026Estimated
Primary Completion Date: Sep 2026Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Patients with non-restorable mandibular molar requiring dental extraction.

Patient medically free from systemic diseases that absolutely contraindicate implant surgery.

Age range: from (18 to 45) years.

Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration (8-12mm).

Extraction sockets with intact bony walls and interradicular bone.

Jumping gap more than 2mm.

Patients with good oral hygiene.

Patients willing to participate in the study's follow-up intervals.

Exclusion Criteria:

Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site impaired the immediate implant placement.

smoker patients.

Pregnant patients.

Patients with para-functional habits (bruxism and clenching)

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 24Estimated
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Mohamad M Marwa, MScContact
mohamad.marwa.1998@gmail.com+201140990087

Similar Studies

Participant Group/Arms

Immediate Implant with Enamel Matrix DerivativeExperimental

Participants will receive an immediate dental implant in the mandibular molar region with the application of enamel matrix derivative (EMD) to the extraction socket. Clinical and radiographic outcomes, including implant stability and peri-implant bone changes, will be evaluated over six months.

Biological: Enamel Matrix Derivative (Emdogain)

Procedure: Immediate Dental Implant Placement

Immediate Implant without Enamel Matrix DerivativeActive Comparator

Participants will receive an immediate dental implant in the mandibular molar region without enamel matrix derivative (EMD). Clinical and radiographic outcomes, including implant stability and peri-implant bone changes, will be evaluated over six months.

Procedure: Immediate Dental Implant Placement