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NCT07726901

Overview

NCT ID: NCT07726901
Lead Sponsor: Samsung Medical CenterOTHER
Official Title: Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation : (COMPASS-AF)
Brief Summary: This study is aimed to compare the clinical efficacy of two different catheter ablation strategies in patients with persistent atrial fibrillation.

Participants will be randomized 1:1 into either the Anatomy-based group or the Emphasize map-guided group

Anatomy-based group : Pulmonary vein isolation (PVI) using pulsed-field ablation (PFA) with a single-shot multielectrode catheter.

Emphasize map-guided group : PVI using radiofrequency (RF) ablation followed by additional EnSite X-guided pathologic substrate modification.

Participants will be followed for 1 year to compare the incidence of any atrial tachyarrhythmia and other clinical parameters between the two groups.
Conditions: Atrial Fibrillation (AF)

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adults aged 19 years or older who have voluntarily provided written informed consent to participate in the study

Patients diagnosed with persistent atrial fibrillation (AF) who are scheduled to undergo catheter ablation for AF.

Exclusion Criteria:

History of prior catheter ablation or MAZE surgery for atrial fibrillation.

Left atrial (LA) diameter exceeding 60 mm.

Patients with end-stage renal disease (ESRD).

History of prior open-heart surgery.

Women who are pregnant, lactating, or of childbearing potential.

Heart failure corresponding to New York Heart Association (NYHA) functional class IV.

Acute coronary syndrome (ACS) experienced within the past 3 months.

Patients with terminal illness and a life expectancy of less than one year.

Any other condition that the investigator deems inappropriate for participation in the study.

Central Contacts: Ju Youn Kim, Ph.DContact
kzzoo921@gmail.com82+ 2-3410-3419