This randomized, triple-blind, placebo-controlled split-mouth clinical trial aims to evaluate the clinical and biochemical efficacy of subgingival pomegranate peel extract gel as an adjunct to scaling and root planing (SRP) in the treatment of Stage II-III periodontitis.
Thirty-two participants diagnosed with Stage II-III periodontitis will receive SRP in all selected periodontal sites. Test sites will receive locally delivered pomegranate peel extract gel, while contralateral control sites will receive a placebo gel. Clinical periodontal parameters, including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP), and gingival crevicular fluid levels of matrix metalloproteinase-8 (MMP-8), will be assessed at baseline, 1 month, 3 months, and 6 months to evaluate whether adjunctive pomegranate peel extract gel improves periodontal healing compared with SRP alone.
Inclusion Criteria:
Exclusion Criteria:
gehadasaad.26@azhar.edu.eg+201092710515
Participants, clinical operators administering the intervention, investigators responsible for clinical evaluation and data analysis, and outcome assessors are blinded to treatment allocation. Test and placebo gels are identical in appearance, consistency, and packaging. Randomization codes are maintained by an independent investigator until completion of data analysis.
Periodontal sites receive scaling and root planing followed by subgingival application of pomegranate peel extract gel.
Periodontal sites receive scaling and root planing followed by subgingival application of placebo gel with identical appearance and consistency.
Evaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodontal Disease
Active Oxygen Releasing Gel With Photodynamic Therapy in Treating Stage III Periodontitis
Evaluation of Hyaluronic Acid and Chlorhexidine Gel as an Adjunct to Minimally Invasive Non-surgical Therapy in the Treatment of Stage III and IV Periodontitis: A Randomized Clinical Trial
Grape Seeds Extract Gel as an Adjunct for the Treatment of Chronic Periodontitis
Evaluation of 2%Bromelain Gel With 0.2%CHX Gel as Subgingival LDD Following SRP in Stage II/III and Grade B Periodontitis -A RCT
Thermosensitive Hyaluronic Gel With Octenidine as an Adjunctive to Subgingival Instrumentation. Spontaneous, Postmarketing Trial With a Medical Device (MD), Split-mouth, Nationwide Multicenter Study Single-blind Randomized Controlled Trial
Placenta Extract Gel as a Periodontal Local Delivery Drug
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis