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NCT07725185

Overview

NCT ID: NCT07725185
Lead Sponsor: Affiliated Hospital of Jiaxing UniversityOTHER
Official Title: Effects of Remimazolam and Propofol on Postoperative Myocardial Injury in Elderly Patients Undergoing General Anesthesia
Brief Summary: This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate its protective efficacy against elevated high-sensitivity cardiac troponin T (hs-cTnT) levels and perioperative myocardial injury.
Conditions: Myocardial Injury
Interventions: Remimazolam

Ages Eligible for Study: Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Age ≥ 65 years

Elderly hospitalized patients scheduled to undergo general anesthesia

American Society of Anesthesiologists (ASA) physical status I-III

Surgery to be performed in the supine position

Ability to communicate with the investigator and to cooperate in completing the assessment scales

Expected duration of surgery ≥ 2 hours

Exclusion Criteria:

Congenital heart disease, severe cardiac conduction block, or implanted cardiac pacemaker;

History of cerebral infarction, cerebral hemorrhage, or stroke within the past 3 months;

Known allergy to remimazolam or propofol;

Severe mental illness, history of analgesic abuse, or addiction to psychotropic drugs;

Patient or family members refuse surgery or anesthesia, or are unable to complete the required questionnaires.