Radiation Therapy and Thymus Function in Young Women With Breast Cancer | NCT07725172

NCT07725172

Overview

NCT ID: NCT07725172
Lead Sponsor: Duke UniversityOTHER
Official Title: Off-Target Effects of Breast Cancer Adjuvant Radiation Therapy on Thymus Function in Young Women
Brief Summary: Breast cancer treatment sometimes includes radiation to the breast or chest wall. There is a small gland, called the thymus, located in the upper chest that may receive a small amount of the radiation aimed at the breast. The goal of this study is to collect blood samples from young women with breast cancer to study the effect of radiation therapy on the thymus gland.
Conditions: Breast Cancer
Interventions: Blood draw for the laboratory assessment

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Women aged 18 to 50 undergoing mastectomy or breast-conserving surgery for breast cancer of any subtype at DUMC and associated satellite centers

Histologic documentation of breast cancer based on pathology

Systemic therapies including hormone therapy, targeted therapy, chemotherapy and immunotherapy as given for breast cancer treatment at the discretion of the treating medical oncologist are allowed and use of such therapies will be documented and included as a covariate

Willing and able to provide written informed consent

Exclusion Criteria:

Prior history of therapeutic high-dose irradiation of the thorax (e.g. for treatment of lung cancer, head/neck cancer, Hodgkin disease, etc., not just radiological imaging alone)

History of thymectomy or treatment with immunosuppressive drugs within the past six months

Individuals with rheumatoid arthritis or other autoimmune conditions

Individuals with Down's syndrome

Male patients

Central Contacts: Duke Radiation Oncology Clinical TrialsContact
RadOnc-Clinical_Trials@dm.duke.edu