Google Maps

NCT07725120

Overview

NCT ID: NCT07725120
Lead Sponsor: Centre Hospitalier Universitaire de NiceOTHER
Official Title: Retrospective Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral Polyneuropathies
Brief Summary: This retrospective single-center observational study will evaluate the impact of age on the diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR) in patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies. Clinical and electrophysiological data collected during routine care between January 2013 and July 2026 will be analyzed. Diagnostic performance will be assessed using receiver operating characteristic (ROC) curve analysis across predefined age groups to determine whether age-adjusted SRAR thresholds improve the differentiation between the two polyneuropathy phenotypes.
Conditions: Polyneuropathies

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Adults aged 18 years or older.

Diagnosis of peripheral sensory polyneuropathy.

Classification as length-dependent (LDN) or non-length-dependent (NLDN) based on clinical and electrophysiological findings.

Available nerve conduction study including sural and radial sensory nerve amplitudes allowing calculation of the SRAR.

Evaluated at the Peripheral Neuromuscular Rare Disease Reference Center, Nice University Hospital, between January 2013 and July 2026.

Exclusion Criteria:

Missing or incomplete clinical or electrophysiological data preventing SRAR calculation.

Unclassifiable neuropathy phenotype.

Technical factors affecting the reliability of nerve conduction studies.