AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration | NCT07725055

NCT07725055

Overview

NCT ID: NCT07725055
Lead Sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-VingtsOTHER
Official Title: AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration
Brief Summary: Primary objective:

- Acquisition and analysis of images for non-medical purposes using the MONA IV system, an adaptive-optics-corrected scanning ophthalmoscope.

Secondary objectives:

To measure the reproducibility of assessments;

To evaluate the detection of progressive changes.
Conditions: Glaucoma Associated With Other Ocular Disorders
Retina Disorder
Interventions

Ages Eligible for Study: Child (0-17)Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Patients:

100 subjects aged 10 to 79 years with a condition that may affect the inner retina (e.g., glaucoma, optic neuropathy, etc.)

100 subjects aged 10 to 80 years with a condition that may affect the outer retina (e.g., AMD, retinitis pigmentosa, etc.)

Male or female

Covered by health insurance

Healthy volunteers:

30 subjects aged over 50 and under 80

30 subjects aged over 18 and under 50

Male or female

Healthy subjects with no known condition that directly or indirectly affects the structure of the eye

Covered by health insurance

Exclusion Criteria:

For all subjects:

Inability to remain motionless on a standard ophthalmic chin rest. RETION_Protocol_v2.0 dated June 10, 2026_IDRCB: 2026-A00324-47 Page 10 of 44

Subjects taking medications or suffering from a medical condition that could interfere with the evaluations planned under the protocol;

Participants allergic to tropicamide in cases where pupil dilation is required. ☞ Wearing glasses or contact lenses to correct a refractive error is not considered an exclusion criterion.