Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials | NCT07725029

NCT07725029

Overview

NCT ID: NCT07725029
Lead Sponsor: Mansoura UniversityOTHER
Official Title: Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials Around Immediate Dental Implants in the Maxillary Esthetic Zone
Brief Summary: Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. After atraumatic teeth extraction, immediate implant placement will be done and buccal jumping gap will be filled by demineralized dentin matrix in study group and control one by demineralized dentin matrix mixed with in injectable platelet rich fibrin.
Conditions: Tooth Extraction
Interventions

Status and Timeline

Status: Completed
Last Update Posted: Jul 24, 2026Actual
Start Date: Jun 1, 2025Actual
Primary Completion Date: Sep 1, 2025Actual
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Patient age ranged between 18-40 years old.

Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior &premolars) by using immediate implant placement.

Cooperative patients with high motivation and good oral hygiene.

Intact socket wall after tooth extraction.

Jumping gap more than 2mm.

Favorable occlusion without presence of parafunctional habits, eg; bruxism and clenching.

Sufficient inter-arch space to accommodate the future prothesis.

Patients able to comply with the required recall visits.

Exclusion Criteria:

Patients with known systemic diseases, which can affect normal bone formation or blood coagulation.

Presence of signs of acute infection or pus formation.

Pregnancy.

Smoking.

Patients on bisphosphonate drug.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 32Actual
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Contacts and Locations

Central Contacts: No data available
Locations: Mansoura

Similar Studies

Participant Group/Arms

group 1Experimental

buccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix for 16 cases

Other: Demineralized dentin matrix grafting material

group 2Experimental

buccal jumping gap following immediate implant placement will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin for 16 cases

Other: Demineralized dentin matrix with injectable platelet rich fibrin