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NCT07723131

Overview

NCT ID: NCT07723131
Lead Sponsor: University of Campinas, BrazilOTHER
Official Title: Structural and Clinical Predictors of Late Cognitive Impairment After Microsurgical Clipping of Ruptured Cerebral Aneurysms: A Retrospective Cohort With Prospective Assessment
Brief Summary: This study investigates the clinical and structural predictors of long-term cognitive impairment in patients who underwent microsurgical clipping for aneurysmal subarachnoid hemorrhage. Using a retrospective cohort with prospective neuropsychological and MRI assessments, it aims to identify factors associated with late cognitive deficits and improve prognostic stratification, rehabilitation planning, and long-term patient care.
Conditions: Subarachnoid Aneurysm Hemorrhage
Microsurgery
Cognitive Impairment

Ages Eligible for Study: Child (0-17)Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Age ≥18 years at the time of aSAH.

Treatment by microsurgical clipping of a ruptured cerebral aneurysm.

Survival until study recruitment.

Ability to understand and sign informed consent.

Exclusion Criteria:

Non-aneurysmal subarachnoid hemorrhage.

Exclusively endovascular treatment.

Previous diagnosis of dementia.

Severe neurological or psychiatric disorders unrelated to aSAH with significant cognitive impact.

Absolute contraindication to MRI.

Severe aphasia preventing adequate neuropsychological evaluation.

Incomplete clinical data.

Inability to attend in-person assessment.