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NCT07722351

Overview

NCT ID: NCT07722351
Lead Sponsor: Medical University of SilesiaOTHER
Official Title: Instrumental Assessment of a Homocysteic Acid-containing Chemical Skin Biostimulator in the Management of Photoaged Mature Skin
Brief Summary: This study evaluated whether a chemical skin biostimulator containing ammonium trichloroacetate, homocysteic acid, phytic acid and citric acid can improve signs of photoaged skin in women with mature skin. Twenty-five women received four treatment sessions two weeks apart, followed by a home-care skincare regimen. Skin firmness, wrinkles, skin texture, hydration, sebum production and, in participants with hyperpigmentation, skin tone uniformity were measured before treatment and at 2 and 12 weeks after the treatment series to determine whether the biostimulator produces lasting improvement in photoaged skin without the downtime associated with traditional chemical peels.
Conditions: Skin Aging
Hyperpigmentation

Status and Timeline

Status: Completed
Last Update Posted: Jul 23, 2026Actual
Start Date: Oct 29, 2025Actual
Primary Completion Date: Apr 1, 2026Actual
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Female, Fitzpatrick skin phototype II

Age 39-69 years

Clinical signs of facial photoaging

Some participants had hyperpigmentation (melasma or post-inflammatory hyperpigmentation)

Exclusion Criteria:

Pregnancy or breastfeeding

Ongoing hormone therapy

Systemic corticosteroid use within 3 months prior to inclusion

Topical retinoid use within 1 month, or oral retinoid use within 6 months, prior to treatment

Chemical peel procedures within 1 month prior to treatment

Use of arbutin and/or hydroquinone within 3 months prior to treatment

Laser-based treatments within 3 months prior to treatment

Active inflammatory dermatoses

Autoimmune diseases

Renal impairment

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 25Actual
Primary Purpose: Treatment
Allocation: N/A
Interventional Model: Single Group Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: No data available
Locations: Department of Practical Cosmetology and Skin Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice

Similar Studies

Participant Group/Arms

Chemical skin biostimulator (ATCA/HoA) plus home-care regimenExperimental

Women with clinical signs of facial photoaging received four sessions, at 14-day intervals, of a topical chemical skin biostimulator containing ammonium trichloroacetate (ATCA), homocysteic acid (HoA), phytic acid and citric acid (PRX plus, WiQO), followed by a standardised home-care regimen consisting of a regenerating cream (morning), a glycolic-acid-containing fluid (evening), and, in participants with hyperpigmentation, a lightening serum applied twice daily to affected areas.

Procedure: Chemical skin biostimulation with ammonium trichloroacetate and homocysteic acid