The goal of this observational study is to learn whether the renin-angiotensin system, measured by angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) in saliva and blood, is associated with periodontal disease severity in adults undergoing cardiovascular evaluation.

The main questions it aims to answer are:

• Are salivary and blood ACE and ACE2 levels different according to periodontal disease severity?
• Do salivary ACE and ACE2 levels reflect the corresponding blood levels?
• Are ACE and ACE2 levels related to clinical measures of periodontal disease?

Participants will:

• Complete medical and dental history assessments.
• Undergo a comprehensive periodontal examination, including measurements of plaque, gingival inflammation, bleeding on probing, probing pocket depth, clinical attachment loss, and the number of remaining teeth.
• Provide saliva and blood samples for laboratory measurement of ACE and ACE2.