Quadroiliac Plane Block for Analgesia After Renal Transplantation | NCT07716566

NCT07716566

Overview

NCT ID: NCT07716566
Lead Sponsor: Kanuni Sultan Suleyman Training and Research HospitalOTHER
Official Title: Analgesic Efficacy of Ultrasound-Guided Quadroiliac Plane Block Versus Surgical Wound Infiltration in Patients Undergoing Renal Transplantation: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial
Brief Summary: Renal transplantation is a major abdominal surgical procedure that may cause moderate to severe postoperative pain. Opioids are commonly used as part of multimodal analgesia; however, opioid-related adverse effects such as sedation, respiratory depression, nausea, vomiting, and constipation may delay recovery and mobilization.

The quadroiliac plane block is an ultrasound-guided interfascial plane block performed near the attachment of the quadratus lumborum muscle to the iliac crest. The technique may provide analgesia over a broad lower abdominal area and may reduce postoperative opioid requirements.

This prospective, randomized, double-blind, controlled clinical trial will compare an ultrasound-guided unilateral quadroiliac plane block with surgical wound infiltration in adult patients undergoing renal transplantation. Participants will be randomly assigned to receive either a quadroiliac plane block with 40 mL of 0.25% bupivacaine or surgical wound infiltration with 10 mL of 0.25% bupivacaine.

All participants will receive standardized multimodal analgesia and intravenous patient-controlled analgesia with tramadol. The primary objective is to compare cumulative tramadol consumption during the first 24 hours after surgery. Postoperative pain scores, dermatomal sensory distribution, motor block, nausea, vomiting, sedation, and quality of recovery will also be evaluated.

Status and Timeline

Status: Recruiting
Last Update Posted: Jul 30, 2026Actual
Start Date: Jul 20, 2026Estimated
Primary Completion Date: Jul 20, 2027Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers?: No
Eligibility Criteria: Inclusion Criteria:

Age between 18 and 80 years

American Society of Anesthesiologists physical status I-III

Scheduled to undergo renal transplantation surgery

Ability to understand the study procedures and postoperative assessments

Provision of written informed consent

Exclusion Criteria:

Known allergy to bupivacaine or other amide-type local anesthetics

Infection at the planned injection site

Coagulopathy or anticoagulant therapy associated with an unacceptable bleeding risk for regional anesthesia

Sepsis

Severe spinal deformity or anatomical abnormality preventing performance of the quadroiliac plane block

Inability to cooperate or communicate reliably

Cognitive impairment or intellectual disability preventing informed consent or reliable outcome assessment

Altered level of consciousness

Breastfeeding

Refusal to participate

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 60Estimated
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Contacts and Locations

Central Contacts: Engin ihsan Turan, principal investigatorContact
enginihsan@hotmail.com

Similar Studies

Participant Group/Arms

Quadro-Iliac Plane Block GroupExperimental

Participants assigned to this group will receive an ultrasound-guided unilateral quadroiliac plane block on the surgical side while under general anesthesia. The block will be performed using 40 mL of 0.25% bupivacaine. All participants will receive the same standardized multimodal analgesic regimen and postoperative intravenous patient-controlled analgesia with tramadol.

Procedure: Ultrasound-Guided Quadroiliac Plane Block

Surgical Wound Infiltration GroupActive Comparator

Participants assigned to this group will receive surgical wound infiltration at the end of surgery. A total of 10 mL of 0.25% bupivacaine will be infiltrated into the subcutaneous tissues along the surgical incision. All participants will receive the same standardized multimodal analgesic regimen and postoperative intravenous patient-controlled analgesia with tramadol.

Procedure: Surgical Wound Infiltration With Bupivacaine