Effect of GMI With and Without NM on LE in Cancer Patients With CIPN

Effect of Graded Motor Imagery With and Without Neural Mobilization on Lower Extremity in Cancer Patients With Chemotherapy-induced Peripheral Neuropathy

The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients. The main questions it aims to answer are:

- Does graded motor imagery yields any added effects in relieving nerve related symptoms due to chemotherapy in lower limbs of cancer patients to the effects of nerve mobilization? Researchers will compare the effects of graded motor imagery as a standalone therapy (Group A) to the effects of graded motor imagery with nerve mobilization (Group B) Participants will take treatment sessions according to their allocated group, two sessions per week for six weeks.

Inclusion Criteria:

• Both male and female
• Age ranging from 31 to 65 years
• Diagnosed cancer patients (stage 1 to 3, cancer of any kind)
• Chemotherapy sessions (antineoplastic drugs) - at least 1 session
• Presence of glove and stocking peripheral neuropathy
• LANSS score greater than 12
• Agreed to give complete follow-up

Exclusion Criteria:

• Any co-morbid conditions that can cause peripheral neuropathy e.g. diabetes, chronic kidney failure
• Any trauma history that can cause peripheral neuropathic symptoms
• Pre-existing nerve entrapment syndromes
• Diagnosed stage 4 cancer patients
• Cancer patients taking palliative chemotherapy