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The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients. The main questions it aims to answer are:
- Does graded motor imagery yields any added effects in relieving nerve related symptoms due to chemotherapy in lower limbs of cancer patients to the effects of nerve mobilization? Researchers will compare the effects of graded motor imagery as a standalone therapy (Group A) to the effects of graded motor imagery with nerve mobilization (Group B) Participants will take treatment sessions according to their allocated group, two sessions per week for six weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A - Graded Motor Imagery | Experimental | Graded motor imagery sessions were provided twice a week for six weeks. Each GMI phase lasted for two weeks. |
|
| Group B - Grade Motor Imagey with Neural Mobilization | Active Comparator | Graded motor imagery with neural mobilization sessions were provided twice a week for six weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Graded Motor Imagery | Other | Graded motor imagery is a series of three steps. The first step, lateral recognition, includes graded left and right judgment exercises. The second step involves imagining the performance of movements and the third, and last step involves performing movements in front of a mirror. |
| Measure | Description | Time Frame |
|---|---|---|
| LANSS | Leeds Assessment of Neuropathic Symptoms and Sign | Baseline, week 3 (mid-intervention), week 6 (post intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Romberg Test | Quantitative version of Romberg Test | Baseline, week 6 (post-intervention) |
| EORTC-QLQ-CIPN20 | European Organization of Research and Treatment of Cancer-Quality of Life Questionnaire-Chemotherapy Induced Peripheral Neuropathy 20 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Faisalabad | Faisalābad | Punjab Province | 38000 | Pakistan |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D009437 | Neuralgia |
| D001259 | Ataxia |
| ID | Term |
|---|---|
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D010146 | Pain |
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Group A was given graded motor imagery Group B was given graded motor imagery with neural mobilization
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|
| Neural Mobilization | Other | Nerve mobilization allows movement between structures of nervous system and its surrounding areas. It is used to mobilize the nervous system and maintain equilibrium inside the nervous system as well as in structures present in its surroundings. |
|
| Baseline, week 6 (post-intervention) |
| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020820 | Dyskinesias |