Phase 2 Study of Glofitamab and Gemcitabine and Oxaliplatin (Glofit-GemOx) Bridging to Lisocabtagene Maraleucel in Relapsed/Refractory Aggressive B-cell Lymphomas
Phase 2 Study of Glofitamab and Gemcitabine and Oxaliplatin (Glofit-GemOx) Bridging to Lisocabtagene Maraleucel in Relapsed/Refractory Aggressive B-cell Lymphomas
The goal of this clinical trial is to assess the clinical efficacy of bridging therapy with glofitamab/gemcitabine/oxaliplatin (Glofit-GemOx) followed by lisocabtagene maraleucel (liso-cel) in relapsed/refractory large B-cell lymphomas. This clinical trial also aims to investigate other efficacy parameters of the combination of Glofit-GemOx plus liso-cel and assess the safety of the combination of Glofit-GemOx bridging plus liso-cel. The main questions it aims to answer are:
This is a multi-center, phase II single-arm study to assess the efficacy and safety of glofitamab/gemcitabine/oxaliplatin (Glofit-GemOx) as bridging therapy followed by lisocabtagene maraleucel (liso-cel) in patients with relapsed/refractory large B-cell lymphomas. Participants will also receive obinutuzumab pre-treatment and undergo apheresis. The U.S. Food and Drug Administration (FDA) has approved obinutuzumab as a treatment option for relapsed/refractory large B-cell lymphomas. Obinutuzumab is a targeted cancer drug called a monoclonal antibody. Obinutuzumab works by attaching to a specific marker on certain white blood cells (including cancerous ones), flagging them so the body's immune system knows which cells to destroy. The U.S. Food and Drug Administration (FDA) has approved glofitamab as a treatment option for relapsed/refractory large B-cell lymphomas. Glofitamab is a T-cell-bispecific antibody that works by bringing the body's immune cells directly to cancer cells. Specifically, glofitamab attaches to cancerous B cells on one side and to T cells (the immune system's "killer" cells) on the other side, helping the T cells recognize and attack the cancer. This process activates the immune system so it can amplify its response and destroy tumor cells. Gemcitabine/oxaliplatin (GemOx) is a standard, widely used chemotherapy treatment for diffuse large B-cell lymphoma that has returned or gotten worse. Gemcitabine is a nucleoside analog chemotherapy agent that stops cancer cells from making new DNA. Cells need DNA to grow and divide so, by blocking this process, gemcitabine slows down or kills the cancer cells. Oxaliplatin is a platinum-based chemotherapy drug that damages the DNA inside cancer cells, preventing them from growing and dividing. This damage causes the cancer cells to stop working properly and, eventually, die. The U.S. Food and Drug Administration (FDA) has approved lisocabtagene maraleucel (liso-cel) as a treatment option for relapsed/refractory large B-cell lymphomas. Lisocabtagene maraleucel is a CAR-T cell therapy made from an individual's own immune (T) cells. A patient's T cells are extracted though a process called leukapheresis and engineered into CAR-T cells that recognize and attack cancer cells. These CAR-T cells are then returned into the body so they can find and kill the cancer. The resulting re-engineered cell product is called lisocabtagene maraleucel. The U.S. Food and Drug Administration (FDA) has not approved glofitamab with gemcitabine and oxaliplatin (Glofit-GemOx) as a treatment for any disease, but has been incorporated into the National Cancer Center Network (NCCN) guidelines as a recommended treatment in the United States for diffuse large B-cell lymphoma that has returned or gotten worse. Participants will receive treatment until completion or until their disease progresses, they experience another disease or illness that prevents further administration of study treatment, they experience unacceptable side effects, they demonstrate an inability or unwillingness to receive the medication regimen, or they withdraw from the study. Participants will be followed for up to 24 months after the last participant is enrolled. It is expected that about 52 people will take part in this research study. Bristol Myers Squibb Company is supporting this research study by providing funding for the clinical trial activities.
Inclusion Criteria:
OR Relapsed or refractory to 1 prior line of systemic lymphoma therapy at any time after initial treatment if patient is ineligible for a stem cell transplant. Previous therapy must have included a CD20-targeted agent and an anthracycline or alkylating agent. Patients may have received steroids and/or polatuzumab-rituximab (without bendamustine), and/or radiation therapy for disease control and/or palliation "holding therapy" between frontline therapy and protocol registration and this will not be considered an additional line of systemic therapy.
Exclusion Criteria:
History of prior malignancy that could affect compliance with the protocol or interpretation of results, except for the following: Non-melanoma skin cancers, in situ malignancies, prostate cancer followed with watchful waiting, indolent lymphoma, any previously treated malignancy felt at low risk for recurrence.
Evidence of disease (such as severe or uncontrolled systemic diseases) that, in the investigator's opinion, make it undesirable for the patient to participate in the study or that would jeopardize compliance with the protocol
Treatment with prior CAR T-cell therapy.
Treatment with prior CD20:CD3 bispecific antibody therapy.
History of or ongoing confirmed progressive multifocal leukoencephalopathy (PML)
Received any investigational drug within 30 days or 5 half-lives (whichever is shorter) before first dose of study drug.
Received a live virus vaccination within 28 days of first dose of study drug.
Concurrent participation in another therapeutic clinical trial.
Current life-threatening illness, medical condition, or organ system dysfunction which, in the Investigator's opinion, could compromise the subject's safety or put the study at risk
Previous treatment with gene therapy product or adoptive T cell therapy
Allogeneic stem cell transplant within 90 days of leukapheresis
Active acute or chronic GVHD requiring immunosuppressive therapy within 6 weeks prior to enrollment
Grade 2 or higher peripheral neuropathy
HIV infection with positive viral titer by PCR. HIV with negative viral titer by PCR is not an exclusion as long as CD4 count is ≥200 and patient is taking combination antiretroviral therapy.
Serologic status reflecting active hepatitis B or C infection
Any active significant infection (e.g., bacterial, viral, or fungal, including subjects with positive cytomegalovirus [CMV] DNA polymerase chain reaction [PCR])
Clinically relevant CNS pathology
Autoimmune disease requiring chronic systemic corticosteroids at a dose of greater than 10 mg of prednisone daily or an equivalent dose of another corticosteroid
Treatment with alemtuzumab, fludarabine, and/or bendamustine within 6 months leukapheresis or cladribine within 3 months of leukapheresis
Known history of hypersensitivity or anaphylaxis to study drug(s) including active product or excipient components.
Breastfeeding or pregnant: Pregnant women are excluded from this study because glofitamab, gemcitabine, oxaliplatin, fludarabine, and cyclophosphamide are agents with the potential for teratogenic or abortifacient effects. Breastfeeding should be discontinued for at least 12 months after last exposure if the mother is treated with these agents.
jabramson@mgh.harvard.edu617-726-8566
jarnason@bidmc.harvard.edu617-667-9235