Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool

ClinicalTrials.gov ID

NCT07704294

Lead Sponsor

King's College LondonOTHER

Overall Status

Not yet recruiting

Study Type

Observational

Enrollment

180Estimated

Last Update Posted

Jul 15, 2026Actual

Start Date

Sep 1, 2026Estimated

Primary Completion Date

Dec 1, 2027Estimated

Completion Date

Dec 1, 2027Estimated

Official Title

Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool (MS Predictor)

Brief Summary

The goal of this observational study is to determine whether genetic information, together with clinical information, can be used to improve prediction of future multiple sclerosis (MS) diagnosis after a first-time episode of optic neuritis. The study will also investigate visual outcomes, quality of life, healthcare use, and the acceptability of using genetic information to predict future health outcomes in people with optic neuritis.

The main outcomes that we aim to assess are:

1. Incident diagnosis of MS following a first episode of optic neuritis, including time to MS diagnosis.
2. Visual outcomes following optic neuritis, including visual acuity, visual field, and colour vision.
3. Clinical care received following optic neuritis, including specialist review, investigations/tests
4. Health-related and vision-related quality of life.
5. Health economic impacts and healthcare utilisation after experiencing optic neuritis
6. Knowledge, attitudes, and practices/behaviours about using genetic information to predict future MS disease risk.

If consented, participants will:

1. Allow researchers to review information from their medical records relating to their optic neuritis diagnosis, investigations, treatments, and outcomes.
2. Be invited to provide a saliva sample for genetic analysis.
3. Complete questionnaires about their lifestyle/risk factors, quality of life, and views on genetic risk prediction.
4. Allow researchers to track long-term health outcomes using information from their NHS records

• Optic Neuritis
• Multiple Sclerosis
• Neuromyelitis Optica Spectrum Disorder
• Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders
• Sarcoid

• No Intervention: Observational Cohort

Ages Eligible for Study

Child (0-17)Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Aged 16 years and above at time of consent
• Previous episode of optic neuritis diagnosed at one of the participating sites

Exclusion Criteria:

• Patients for whom data relating to the first episode of ON are not available in the medical record at a participating site
• Children <16 years at the time of recruitment

Observational Model

Cohort

Time Perspective

Retrospective

Lead Sponsor

King's College LondonOTHER

Collaborators

Guy's and St Thomas' NHS Foundation TrustOTHER

King's College Hospital NHS TrustOTHER

Moorfields Eye Hospital NHS Foundation TrustOTHER

tasanee.braithwaite@kcl.ac.uk+44 20 7188 7188

james.mchugh@kcl.ac.uk+44 20 3299 9000

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