Study on the Effect of Fecal Microbiota Transplantation on Eradication of Refractory Helicobacter Pylori Infection

Study on the Effect of Fecal Microbiota Transplantation on Eradication of Refractory Helicobacter Pylori Infection

To determine whether regulating the gut microbiota can contribute to the eradication of refractory H. pylori infection.

Inclusion Criteria:

• 1. Ages 18-70
• 2. Hp infection treatment failed ≥4 times with guidelines-recommended therapies
• 3. Patients with early gastric cancer, peptic ulcer, gastric MALT lymphoma, atrophic gastritis and other diseases requiring the eradication of Hp.

Exclusion Criteria:

• 1. Antibiotics and bismuth were taken within 4 weeks before this treatment; Or had taken PPI, H2 receptor antagonist, P-CAB within 2 weeks prior to treatment;
• 2. Pregnant or lactating women;
• 3. Those who are allergic to the investigational drugs used in this test or have contraindications;
• 4. Participated in other drug trials within 3 months before the treatment of this trial;
• 5. There are other serious diseases that affect the evaluation of this study at the same time, or they cannot correctly express their own complaints and cannot cooperate;
• 6. Subjects with dysphagia;
• 7. Patients with malignant tumors, serious concomitant diseases, severe ulcer bleeding or perforation;
• 8. Patients judged by the investigator to be unsuitable for clinical trials.
• 9. Those who do not want to sign the informed consent for the study.