Effects of Blood Gas Perturbations | NCT07701603 | Trialant

Effects of Blood Gas Perturbations | NCT07701603 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Gas perturbations	Experimental	Each participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h.	Other: Gas perturbation

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Gas perturbation	Other	Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Diaphragm contractility	Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.	Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec

Other Outcomes

Measure	Description	Time Frame
Quadriceps contractility	Quadriceps contractility will be assess before, during and following the gas exposures and respiratory muscle contractions	Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec.

Contacts/Locations Module