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This study aims to investigate the efficacy of transcranial direct current stimulation (tDCS) in patients with post-stroke aphasia (PSA) and to explore its potential neural mechanisms. The study will recruit PSA patients and provide them with 14 tDCS sessions over 7 days, along with speech therapy. Language Behavior Scale scores and resting-state functional MRI scans will be collected before and after the intervention. In addition, a retrospective comparison will be conducted of language function and resting-state fMRI changes in a group of PSA patients who received only speech therapy; these patients did not undergo any physical intervention but received only speech therapy. Changes in Language Behavior Scale scores and functional connectivity (FC) before and after treatment in the speech therapy-only group will be analyzed and compared with those in the tDCS intervention group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS group | Experimental | PSA patients enrolled in the tDCS group received tDCS treatment twice daily for 7 consecutive days, along with 7 days of speech-language therapy. The current intensity was 2 mA, and each treatment session lasted 20 minutes. |
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| The speech-language therapy group | No Intervention | The speech-language therapy group received only 7 days of speech-language therapy. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation | Other | As a non-invasive brain stimulation technique, tDCS offers advantages such as convenience, safety, and low cost. Its mechanism of action involves regulating neuronal activity in the brain by applying a weak direct current to the scalp. |
| Measure | Description | Time Frame |
|---|---|---|
| Aphasia quotient (AQ) | The Aphasia Battery of Chinese (ABC) is a standardized Chinese adaptation of the Western Aphasia Battery (WAB). The Aphasia Quotient (AQ) is a composite score that reflects the overall severity of language impairment. The AQ score ranges from a minimum of 0 to a maximum of 100. Higher scores indicate better language function (i.e., less severe impairment). | Baseline, immediately after all interventions have ended |
| Measure | Description | Time Frame |
|---|---|---|
| rs-fMRI | Baseline, immediately after all interventions have ended |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jian Guan | Contact | +86-19810696998 | 1003935828@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| transcranial direct current stimulation (tDCS) | Recruiting | Hefei | Anhui | China |
Individual participant data will not be shared with other researchers due to patient privacy protection and the limitations of the informed consent form.
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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