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| Name | Class |
|---|---|
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
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The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be possible. The tool created should help improve planning for organ donation and provide families and healthcare teams with more accurate information.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The study cohort will consist of patients eligible for donation after circulatory determination of |
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| Measure | Description | Time Frame |
|---|---|---|
| To develop a clinically applicable model to predict dying duration in a cohort of patient eligible for donation after circulatory death | Specifically, we aim at assessing the predictive ability of blood-based brain biomarkers, optic nerve sheet diameter as measured by head computed tomography (CT) scans as a surrogate of intracranial pressure and autonomic dysfunction as reflected by abnormal heart rate variability (HRV) to predict the dying duration. | The models will be built to predict death within 30, 60 and 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of the brain-to-heart model to existing models | Our secondary aim will be to compare the created models with available models (e.g., DCD-N, UNOS, Wisconsin) and to physician gestalt | The models will be compared for death within 30, 60 and 120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
Exclusion criteria will consist of :
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ICU
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rebecca Grey Clinical Research Coordinator | Contact | 604-875-4111 | 68336 | cerebri.research@ubc.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cumming School of Medicine | Calgary | Alberta | Canada |
Data will be avaiable to be shared on demand. However, statistical analysis and prediction modeling computer code will be made publicly available on GitHub.
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Blood-based brain biomarkers
| UBC/East Kootenay Regional Hospital | Cranbrook | British Columbia | Canada |
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| Kelowna General Hospital | Kelowna | British Columbia | Canada |
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| Royal Columbian Hospital | New Westminster | British Columbia | Canada |
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| Surrey Memorial Hospital | Surrey | British Columbia | Canada |
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| Vancouver General Hospital | Vancouver | British Columbia | V5Z1M9 | Canada |
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| University of Manitoba Health Sciences Center | Winnipeg | Manitoba | Canada |
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| University Hospital - London Health Sciences Centre | London | Ontario | N6A 3K7 | Canada |
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| Lakeridge Health | Oshawa | Ontario | L1G 8A2 | Canada |
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| Children's Hospital of Eastern Ontario (CHEO) | Ottawa | Ontario | Canada |
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| St Paul hospital | Vancouver | Canada |
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