High-intensity Interval Training Versus Moderate Intensity Continuous Training on Gut Microbiota in Non-alcoholic Fatty Liver

High-intensity Interval Training Versus Moderate Intensity Continuous Training on Gut Microbiota in Non-alcoholic Fatty Liver

To compare High-Intensity Interval Training versus moderate intensity continuous training on gut microbiota in Non- Alcoholic Fatty Liver.

non- Alcoholic Fatty Liver disease affects approximately 25% of the global population, with its prevalence increasing due to lifestyle changes such as poor diet and sedentary behavior. non- Alcoholic Fatty Liver disease is often associated with metabolic disorders, including insulin resistance, obesity, and type 2 diabetes. Emerging evidence suggests that alterations in gut microbiota may contribute to the pathophysiology of non- Alcoholic Fatty Liver disease, influencing liver function, inflammation, and metabolic regulation. However, there is limited research exploring the effects of interventions such as exercise and dietary changes on gut microbiota composition in non- Alcoholic Fatty Liver disease patients The findings of this study could have important clinical implications, particularly for developing tailored lifestyle interventions for non- Alcoholic Fatty Liver disease patients. As gut microbiota dysbiosis is increasingly recognized as a key player in the development and progression of non- Alcoholic Fatty Liver disease, interventions targeting microbiota balance could offer novel therapeutic approaches for managing this prevalent and potentially severe condition

Inclusion Criteria:

1. Patients from both genders aged 40 - 60 years old diagnosed with Non-alcoholic Fatty Liver disease by ultrasonography.
2. Body mass index will range from 30 to 34.9 kg/m².
3. Patients with central obesity (waist circumference 90 cm for men and 85 cm for women).
4. Patients who have taken no regular exercise in the last year (<3 times/week and 30 min/time.
5. No antibiotic or probiotic use for at least last 3 months.
6. Medical drugs such as metformin, sulfonylureas, statins, and blood pressure medication were eligible, as well as stable.

Exclusion Criteria:

1. History of liver cirrhosis or other chronic liver diseases.
2. Use of medications affecting gut microbiota (e.g., laxatives, metformin, proton pump inhibitors).
3. Recent gastrointestinal infections or surgeries.
4. Diabetes Mellitus type 1 or uncontrolled type 2.
5. Cardiovascular, respiratory, or musculoskeletal disorders limiting exercise capacity.
6. Active smokers.
7. Pregnancy or breastfeeding.
8. Uncontrolled hypertension.
9. Communication disorders.
10. Bleeding disorders.