Adropin Levels in Periodontal Disease

Adropin Levels in GCF and Serum of Periodontitis Patients

This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.

Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.

Inclusion Criteria:

• having at least 20 natural teeth, excluding third molars
• having no systemic disease
• non-smokers
• Diagnosed with periodontally health and periodontitis patients

Exclusion Criteria:

• having any systemic diseases
• smoking
• current pregnancy or lactation
• a history of periodontal treatment in the past 6 months
• using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.