Adropin Levels in Periodontal Disease | NCT07695857

Studies
Adropin Levels in Periodontal Disease

NCT07695857

Sponsor

Giresun University

Status

Completed

Last Update Posted

Jul 10, 2026Actual

Enrollment

60Actual

Phase

Not provided

Conditions

Periodontitis

Interventions

Nonsurgical periodontal therapy

Countries

Turkey (Türkiye)

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

ID	Type	Description	Link
SAĞ-BAP-A-150219-33	Other Grant/Funding Number	Giresun University Scientific Research Projects Coordination Unit

Status Module

Record Verification Date

Jan 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Apr 2, 2018Actual

Primary Completion Date

Sep 2, 2020Actual

Completion Date

Nov 6, 2020Actual

First Submitted Date

Jul 6, 2026

First Submission Date that Met QC Criteria

Jul 6, 2026

First Posted Date

Jul 10, 2026Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jul 6, 2026

Last Update Posted Date

Jul 10, 2026Actual

Name	Class
Aydin Adnan Menderes University	OTHER

Oversight Module

Has Data Monitoring Committee (DMC)

Not provided

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.

Detailed Description

Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

60Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Group 1: Periodontally healthy individuals
Group 2: Periodontitis patients			Procedure: Nonsurgical periodontal therapy

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Nonsurgical periodontal therapy	Procedure	Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
1. Adropin levels	Changes in Adropin levels before and after periodontal therapy	Baseline and at 6 weeks after therapy

Secondary Outcomes

Measure	Description	Time Frame
TNF-alfa levels	Changes in TNF-alfa levels before and after periodontal therapy	baseline and at 6 weeks after therapy

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

having at least 20 natural teeth, excluding third molars
having no systemic disease
non-smokers
Diagnosed with periodontally health and periodontitis patients

Exclusion Criteria:

having any systemic diseases
smoking
current pregnancy or lactation
a history of periodontal treatment in the past 6 months
using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

27 Years

Maximum Age

49 Years

Standard Ages

Adult

Study Population

Criteria for healthy control group: BOP < 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction.

Criteria for periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Giresun University		Giresun			Turkey (Türkiye)

Condition Browse Module

MeSH Terms

ID	Term
D010518	Periodontitis

Ancestor Terms

ID	Term
D010510	Periodontal Diseases
D009059	Mouth Diseases
D009057	Stomatognathic Diseases

Browse Leaves

Not provided

Browse Branches

Not provided