Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations

Comparing corneal topographic changes and corneal high-order aberrations for women planning to use oral contaceptive pills before and after the usage of the pills

Inclusion Criteria:

• Female participants aged 18-40 years.
• Prescribed combined oral contraceptive pills as part of routine gynecological care.
• Willing to undergo corneal topography/tomography before starting treatment and after 1 year.
• No previous history of corneal disease or ocular surgery.
• Able to provide informed consent.

Exclusion Criteria:

• Keratoconus or suspected corneal ectasia.
• Corneal opacity, dystrophy, degeneration, or scarring.
• Previous ocular surgery or significant ocular trauma.
• Current contact lens use or recent contact lens use without adequate discontinuation period.
• Active ocular surface disease or severe dry eye.
• Glaucoma, uveitis, retinal disease, or other significant ocular pathology.
• Diabetes mellitus, autoimmune disease, thyroid disease, pregnancy, or lactation.
• Use of other hormonal therapy or systemic medications known to affect corneal parameters.

Premenopausal women aged 18-40 years attending the Ophthalmology Department at Sohag University Hospital who are prescribed combined oral contraceptive pills by their gynecologist as part of routine clinical care. Participants will undergo corneal topography and tomography before starting treatment and after 1 year of oral contraceptive use.