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This study is aimed to evaluate the efficacy and safety of Fosrolapitant and Palonosetron for Antibody-drug conjugate-induced nausea and vomiting
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fosrolapitant and Palonosetron + dexamethasone + placebo | Experimental | Use this field to provide additional information about the arm, including a description of the intervention(s) administered. |
|
| fosaprepitant dimeglumine for injection+palonosetron hydrochloride injection+dexamethasone | Active Comparator | Use this field to provide additional information about the arm, including a description of the intervention(s) administered. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fosrolapitant and Palonosetron for injection | Drug | • Experimental: Drug：Fosrolapitant and Palonosetron for injection Drug：Dexamethasone Drug: placebo • Active Comparator: Drug：HR20013 placebo Drug: fosaprepitant dimeglumine for injection Drug：Palonosetron injection Drug: Dexamethasone |
| Measure | Description | Time Frame |
|---|---|---|
| Complete response rate | Within 14 days after ADC administration |
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Inclusion Criteria:
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Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| li huiping chief physician | Contact | +86-13811012595 | huipingli2012@hotmail.com |
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Drug: Fosrolapitant and Palonosetron；dexamethasone Drug: fosaprepitant dimeglumine for injection；palonosetron
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|
| ID | Term |
|---|---|
| D009325 | Nausea |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077924 | Palonosetron |
| D007267 | Injections |
| ID | Term |
|---|---|
| D011812 | Quinuclidines |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006571 | Heterocyclic Compounds |
| D007546 | Isoquinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D004333 | Drug Administration Routes |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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