Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU

Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU

This is a pilot study to examine the effects of melatonin on the sleep patterns of critically ill patients. Patients will have their sleep patterns measured with a device attached to their head with a headband then be given a dose of melatonin. Their participation in the study will last two days.

Inclusion Criteria:

• 18 years or older, admitted to the ICU
• Expected length of stay of at least 48 hours
• Not mechanically ventilated
• Able to take oral medications.
• Hemodynamically stable as determined by the treating ICU physician
• Able to provide informed consent or have consent provided by a legally -authorized representative.

Exclusion Criteria:

• Mechanically ventilated
• Currently using melatonin prior to ICU admission,
• Have neurological conditions that may significantly alter sleep architecture, such as traumatic brain injury, stroke, or severe dementia.
• Pregnant or lactating individuals
• Those individuals with a comfort measures-only status