Mild Cognitive Impairment and Neuromodulation

MCI - Mild Cognitive Impairment and Neuromodulation

This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.

This parallel 2 arm study is sham controlled and collected over 6 study visits. Participants will receive MRI and CT scans, LIFU neuromodulation, cognitive assessments, and questionnaires batteries to assess tolerability and functional outcomes in an MCI population.

Inclusion Criteria:

• Montreal Cognitive Assessment (MoCA) scores between 18-23 inclusive, and able to consent to their own medical care.

Exclusion Criteria:

• Claustrophobia
• MRI contraindications (pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, or other implants)
• CT contraindications (pregnancy)
• Non-AD etiology (eg. Lewy body disease, vascular dementia, alcohol/drug related damage)
• Taking anti-amyloid antibodies
• Neuromod within 6 months of the study
• History of other neurological disorder
• Hx of head injury with LOC > 10 min
• Active alcohol or drug dependence