This study aimed to evaluate the effect of non-surgical periodontal treatment (NSPT) on oral health-related quality of life in patients with hemophilia using the Oral Health Impact Profile-14 (OHIP-14) questionnaire. In addition, clinical periodontal parameters and demographic characteristics before and after NSPT were assessed and compared with systemically healthy individuals. A total of 71 patients with hemophilia (60 with Hemophilia A and 11 with Hemophilia B) and 75 healthy individuals were included in the study and grouped according to their periodontal status. Demographic data and oral health-related behavioral characteristics were evaluated. Clinical periodontal parameters and OHIP-14 scores were recorded before treatment and at the sixth week after treatment. All collected data were analyzed statistically. The study aims to determine the relationship between periodontal treatment outcomes and oral health-related quality of life in individuals with hemophilia.

Inclusion Criteria:

• Adults aged 18 to 64 years.
• Diagnosis of hemophilia A or hemophilia B (hemophilia group) or systemically healthy individuals/individuals with medically controlled systemic disease (control group).
• Presence of at least 20 natural teeth, excluding third molars and teeth with orthodontic appliances.
• Ability to provide written informed consent.
• Willingness and ability to comply with study procedures

Exclusion Criteria:

• Presence of bleeding disorders other than hemophilia A or B.
• Uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus or uncontrolled hypertension).
• Use of medications known to affect periodontal tissues (e.g., calcium channel blockers, anticonvulsants, or immunosuppressive agents).
• Fewer than 20 natural teeth.
• Inability or unwillingness to provide informed consent or comply with study procedures.