MICRORAD is a pioneering 48-month translational research project that investigates the potential health and environmental impacts of micro- and nanoplastics (MNPs) released from medical devices when exposed to ionizing radiation. In radiation oncology, thermoplastic masks (TPMs) are standard immobilization tools, particularly for head and neck (HN) cancer patients. Globally, approximately 2.65 million TPMs are used annually for HN patients radiotherapy and additional 8 to 10 million for the other tumor types. TMPs are repeatedly subjected to high-energy X-rays and frequent handling, raising concerns about polymer degradation and the release of MNPs, which may interfere with treatment efficacy or contribute to radiation toxicity.

MICRORAD is the first translational study to explore this phenomenon by integrating clinical oncology, materials science, radiobiology, and data science. The project will analyze radiation-induced changes in TPMs, quantify MNP release, and assess their biological effects through in vitro, in vivo, and clinical studies.

Using advanced detection techniques, the project will characterize MNPs and trace their biodistribution, while a clinical pilot will correlate MNP exposure with treatment outcomes. Data integration, biostatistics, and AI-based modeling will support the translation of findings into clinical guidelines, policy briefs, and public communication.

A multidisciplinary team will collaborate to ensure real-world impact. By bridging oncology and environmental health, MICRORAD aims to establish eco-oncology as a new field, contributing to patient safety and sustainable innovation.

Inclusion Criteria:

• Any stage head and neck cancer patients
• Eastern Cooperative Oncology Group performance status 0-2
• Undergoing radiotherapy with/without cisplatin chemopotentiation
• Signed informed consent

Exclusion Criteria:

• Pregnancy or lactation
• Mental illness
• Prior or concurrent malignancies
• Immunotherapy or immunosuppressive therapy
• Immune diseases

Patients with head and neck malignancies undergoing radiation therapy