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| ID | Type | Description | Link |
|---|---|---|---|
| U24AG072699 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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8-week randomized intervention (with 3-month follow-up) that examines the impact of increased sociable behavior on emotional well-being and immune health profile
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sociable (extraverted) behavior | Experimental | Participants asked to act more outgoing and talkative |
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| Daily routine list | Sham Comparator | Participants asked to list their daily routines without changing behavior |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sociable (extraverted) behavior | Behavioral | Participants asked to act more sociable (extraverted) 3 days a week for 6 weeks on days of their choosing with the goal of promoting social connection. 8-week study includes week 0 pre-test measures and week 1 baseline of sociable behavior "as usual." |
| Measure | Description | Time Frame |
|---|---|---|
| Self-reported loneliness (survey) | Responses to loneliness sub-scale of Comprehensive Inventory of Thriving | From enrollment to end of study period at 8 weeks |
| Self-reported positive and negative affect (survey) | Responses to 12-item survey, Affect-Adjective Scale | From enrollment to end of study period at 8 weeks |
| Immune gene profile | Changes to immune gene profile assayed in dried blood spots | From enrollment to end of study period at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Self-reported psychological well-being (survey) | Responses to the Mental Health Continuum-Short Form | From enrollment to end of study period at 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elissa Eppel, PhD | UC San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychology | Riverside | California | 92521 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38897331 | Background | Yang YS, Wynn JK, Cole S, Green MF. Stress-related gene regulation: Do isolated and connected individuals differ? Brain Behav Immun. 2024 Aug;120:372-378. doi: 10.1016/j.bbi.2024.06.013. Epub 2024 Jun 17. | |
| 21243077 | Background | Cole SW. Social regulation of human gene expression. Curr Dir Psychol Sci. 2009 Jun 1;18(3):132-137. doi: 10.1111/j.1467-8721.2009.01623.x. |
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| ID | Term |
|---|---|
| D000092862 | Psychological Well-Being |
| ID | Term |
|---|---|
| D010549 | Personal Satisfaction |
| D001519 | Behavior |
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| 39098435 | Background | Ricon-Becker I, West TN, Fredrickson BL, Kaplan DM, Mehl MR, Raison CL, Cole SW. Predicting psychosocial intervention response from baseline gene expression. Brain Behav Immun. 2024 Oct;121:331-339. doi: 10.1016/j.bbi.2024.08.004. Epub 2024 Aug 2. |
| 20630660 | Background | Cole SW. Elevating the perspective on human stress genomics. Psychoneuroendocrinology. 2010 Aug;35(7):955-62. doi: 10.1016/j.psyneuen.2010.06.008. Epub 2010 Jul 13. |