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The study examines the immediate effect of soleus pushup exercise on cardiometabolic and hormonal functions among hypothyroid patients.
The primary characteristic of hypothyroidism is sluggish metabolism, which is usually associated with abnormal weight gain, lethargy, constipation, heavy menstrual bleeding, hair loss, cold intolerance, and bradycardia. Importantly, these symptoms have been linked to reduced glucose tolerance and insulin sensitivity though glucose turnover and plasma insulin concentration are elevated. These metabolic changes result in hyperlipidemia, hypercholesterolemia, and elevated insulin resistance, and circulatory low-density lipoprotein cholesterol and total triglyceride levels. Hormonal replacement therapy, the primary treatment for hypothyroidism, partially restores the thyroid function and tappers down the disease symptoms. However, the therapy is associated a plethora of side effects, thus alternative therapies are warranted.
The effect of exercise on thyroid function and metabolism among patients with hypothyroidism is still equivocal. The soleus pushup exercise, a localized exercise that stimulates mainly oxidative metabolism, has been shown to have promising, favorable changes in systemic metabolism. Therefore, the current study compares metabolic and hormonal responses to soleus pushup exercise in patients with hypothyroidism versus healthy controls.
Patients diagnosed with hypothyroidism are recruited to participate in the study. Cardiovascular and circulatory, metabolic, and hormonal measures are determined from blood samples obtained from the patients. Age- and gender-matched healthy individuals are recruited to serve as controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypothyroid patients | Experimental | Hypothyroid patients |
|
| Health controls | Experimental | Health controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Soleus pushup exercise | Behavioral | The participants are given the soleus push-up exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total cholesterol | Total cholesterol will be measured in blood and reported in mg/dL. | 3 hours |
| Triglycerides | Triglycerides will be measured in blood and reported in mg/dL. | 3 hours |
| HDL-C | High-density lipoprotein cholesterol will be measured in blood and reported in mg/dL. | 3 hours |
| LDL-C | Low-density lipoprotein cholesterol will be calculated using the lipid profile and reported in mg/dL. | 3 hours |
| VLDL-C | Very-low-density lipoprotein cholesterol will be calculated from triglycerides and reported in mg/dL. | 3 hours |
| Non-HDL cholesterol | Non-HDL cholesterol will be calculated as total cholesterol minus HDL-C and reported in mg/dL. | 3 hours |
| Apolipoprotein A-I | Apolipoprotein A-I will be measured in blood and reported in mg/dL. | 3 hours |
| Apolipoprotein B | Apolipoprotein B will be measured in blood and reported in mg/dL. | 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rehabilitation Sciences | Irbid | Irbid Governorate | 22110 | Jordan |
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| ID | Term |
|---|---|
| D007037 | Hypothyroidism |
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| D006980 | Hyperthyroidism |
| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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The intervention is given to hypothyroid patients and healthy controls.
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| Lipoprotein(a) | Lipoprotein(a) will be measured in blood and reported in mg/dL or nmol/L, depending on the laboratory assay. | 3 hours |
| Fasting blood glucose | Fasting blood glucose will be measured in blood and reported in mg/dL. | 3 hours |
| Random blood glucose | Random blood glucose will be measured in blood and reported in mg/dL. | 3 hours |
| HbA1c | Glycated hemoglobin will be measured in blood and reported as a percentage. | 3 hours |
| Insulin | Insulin will be measured in blood and reported in µIU/mL or mIU/L, depending on the laboratory assay. | 3 hours |
| Glucagon | Glucagon will be measured in blood and reported in pg/mL. | 3 hours |
| Catecholamines | Catecholamines will be measured in blood and reported in pg/mL. | 3 hours |
| Thyroid-stimulating hormone | Thyroid-stimulating hormone will be measured in blood and reported in mIU/L or µIU/mL, depending on the laboratory assay. | 3 hours |
| Triiodothyronine | Triiodothyronine will be measured in blood and reported in ng/dL. | 3 hours |
| Thyroxine | Thyroxine will be measured in blood and reported in µg/dL. | 3 hours |
| Brain-derived neurotrophic factor | Brain-derived neurotrophic factor will be measured in blood and reported in pg/mL or ng/mL, depending on the laboratory assay. | 3 hours |
| Leptin | Leptin will be measured in blood and reported in ng/mL. | 3 hours |
| Adiponectin | Adiponectin will be measured in blood and reported in µg/mL. | 3 hours |
| Glucagon-like peptide | Glucagon-like peptide will be measured in blood and reported in pmol/L or pg/mL, depending on the laboratory assay. | 3 hours |
| Heart rate | Heart rate will be measured using the standard auscultatory method and reported in beats per minute. | 3 hours |
| Systolic blood pressure | Systolic blood pressure will be measured using the standard auscultatory method and reported in mmHg. | 3 hours |
| Diastolic blood pressure | Diastolic blood pressure will be measured using the standard auscultatory method and reported in mmHg. | 3 hours |
| Pulse pressure | Pulse pressure will be calculated as systolic blood pressure minus diastolic blood pressure and reported in mmHg. | 3 hours |
| Rate-pressure product | Rate-pressure product will be calculated as heart rate multiplied by systolic blood pressure and reported in bpm × mmHg. | 3 hours |
| Mean arterial pressure | Mean arterial pressure will be calculated as diastolic blood pressure plus one-third of pulse pressure and reported in mmHg. | 3 hours |
| D044882 |
| Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |