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This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will receive ozone disinfection at one implant site and conventional disinfection at the paired site according to a randomized allocation. Implant stability will be assessed immediately after implant placement using insertion torque and resonance frequency analysis (Implant Stability Quotient, ISQ), and secondary stability will be evaluated by ISQ measurements at the 3-month follow-up during healing abutment placement. The study will determine whether ozone disinfection improves implant stability during the early osseointegration period.
Primary implant stability is a key determinant of successful osseointegration and long-term implant survival. Various implant site disinfection methods have been proposed to reduce the microbial load before implant placement. Ozone possesses antimicrobial and biostimulatory properties and may improve the biological environment for implant healing compared with conventional implant site disinfection.
The purpose of this randomized split-mouth controlled clinical trial is to compare ozone implant site disinfection with conventional implant site disinfection in terms of primary and early secondary implant stability.
Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will be enrolled. According to a randomized split-mouth design, one implant site will receive ozone disinfection before implant placement, whereas the paired implant site will receive conventional disinfection. This design allows each participant to serve as their own control, thereby minimizing inter-individual variability.
Primary implant stability will be assessed immediately after implant placement using insertion torque measurements and resonance frequency analysis (Implant Stability Quotient, ISQ). Secondary implant stability will be evaluated by resonance frequency analysis at the 3-month follow-up during healing abutment placement. All clinical procedures will be standardized and performed by experienced clinicians. The study aims to determine whether ozone implant site disinfection provides superior implant stability during the early osseointegration period compared with conventional implant site disinfection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ozone Disinfection | Experimental | Implant sites assigned to the experimental intervention receive ozone disinfection before dental implant placement. |
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| Conventional Disinfection | Experimental | Implant sites assigned to the control intervention receive conventional implant site disinfection before dental implant placement. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ozone Implant Site Disinfection | Procedure | Before dental implant placement, the implant site assigned to the experimental intervention is disinfected using ozone according to the study protocol. In this randomized split-mouth design, each participant receives ozone disinfection at one implant site, while the paired contralateral or symmetrical implant site receives conventional disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ. |
| Measure | Description | Time Frame |
|---|---|---|
| Primary Implant Stability (Insertion Torque) | Primary implant stability will be assessed immediately after implant placement by measuring insertion torque (Ncm). | Immediately after implant placement |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry, Adıyaman University | Adıyaman | Merkez | 02030 | Turkey (Türkiye) |
Individual participant data will not be made publicly available because of participant confidentiality and institutional data-sharing policies.
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Participants are enrolled in a randomized split-mouth study design. Each participant receives both interventions at paired implant sites in symmetrical or contralateral edentulous areas. One implant site is assigned to ozone disinfection and the paired implant site to conventional disinfection before dental implant placement, allowing within-participant comparison.
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| Conventional Socket Disinfection | Procedure | Before dental implant placement, the implant site assigned to the control intervention is disinfected using the conventional disinfection protocol. In this randomized split-mouth design, each participant receives conventional disinfection at one implant site, while the paired contralateral or symmetrical implant site receives ozone disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ. |
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