Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2025-A02657-42 | Registry Identifier | RCB |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities. It affects between 0.7% and 16% of European adults over 70 years of age (1). Recent studies suggest that the faecal microbiota may be altered with ageing but also according to sarcopenic status. Furthermore, no study has currently published data on the relationship between salivary microbiota and sarcopenic status. The main hypothesis of this study is that a decrease in salivary microbiota richness could be associated with impaired handgrip strength in the ageing subject.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Participants | Experimental | Collection of saliva and stool samples for microbiota analysis and assessment of handgrip strength in adults aged over 70 years. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salivary and fecal microbiota sampling and muscle strength assessment | Procedure | Collection of saliva and stool samples for microbiota analysis and assessment of handgrip strength in adults aged over 70 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Salivary microbiota richness | Salivary microbiota richness (gene richness/alpha diversity) measured from saliva samples. | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal microbiota diversity | Assessment of fecal microbiota diversity from stool samples and its association with maximal handgrip strength. | 15 days |
| Title: Fecal microbiota richness | Assessment of fecal microbiota richness according to handgrip strength and sarcopenia status. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Prof. DECHELOTTE | Contact | +33 2 32 88 56 70 | pierre.dechelotte@chu-rouen.fr | |
| HERVET | Contact | mylene.hervet@chu-rouen.fr |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rouen University Hospital | Rouen | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 15 days |
| Salivary microbiota diversity | Assessment of salivary microbiota diversity from saliva samples and its association with maximal handgrip strength. | 15 days |
| Fecal microbiota richness according to sarcopenia status | Comparison of fecal microbiota richness between participants with and without sarcopenia. | 15 days |
| handgrip strength | Identification of microbiological and clinical factors associated with lower maximal handgrip strength. | 15 days |
| Risk factors associated with low microbiota genomic diversity | Identification of factors associated with reduced microbial gene richness and diversity in saliva and stool samples. | 15 days |