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This study is evaluating whether Steri-Strips® provide additional benefits when used after cesarean section (C-section) surgery. Steri-Strips are adhesive strips that are commonly placed over a surgical incision to provide support while the wound heals. At our hospital, Steri-Strips are routinely used after C-sections in addition to standard wound closure techniques, although they are not considered part of the standard recommended closure method.
Researchers want to determine whether adding Steri-Strips actually reduces wound complications such as infection, fluid collection under the skin, or reopening of the incision. Previous studies have shown mixed results, with some suggesting little difference in wound healing outcomes while others reported differences in scar appearance. Steri-Strips may also increase costs, add time to the surgery, and occasionally cause skin irritation or allergic reactions.
Participants in this study will be randomly assigned to one of two groups. One group will receive standard cesarean wound closure with Steri-Strips, while the other group will receive standard wound closure without Steri-Strips. Researchers will compare wound healing, complications, patient outcomes, and costs between the two groups.
The goal of this study is to determine whether Steri-Strips improve recovery after cesarean delivery and whether their routine use is beneficial and cost-effective. The findings may help guide future recommendations for cesarean wound care and improve outcomes for patients undergoing C-section delivery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard Closure + Steri-Strips | Experimental | Participants undergo standard cesarean skin closure followed by application of Steri-Strip™ skin closure strips according to a standardized study protocol. |
|
| Standard Closure Alone | Active Comparator | Participants undergo standard cesarean skin closure without application of Steri-Strip™ skin closure strips. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Steri-Strip™ Skin Closures | Device | Application of Steri-Strip adhesive skin closure strips following standard cesarean section wound closure according to a standardized protocol. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Cesarean Section Wound Complications | Composite incidence of postoperative wound complications including surgical site infection, wound seroma, and wound separation/dehiscence following cesarean delivery. | Within 30 days postpartum |
| Measure | Description | Time Frame |
|---|---|---|
| Length of Hospital Stay | Duration of hospitalization measured from cesarean delivery until discharge. | From cesarean delivery until hospital discharge (up to 7 days) |
| Readmission Related to Wound Complications |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthew Perera, DO, MS | Contact | 8184800214 | matthew.perera@ruhealth.org |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Riverside University Health System Medical Center | Recruiting | Moreno Valley | California | 92555 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40114334 | Background | Herman A, Kerre S, Stras A, Desmedt B. Two Additional Cases of Allergic Contact Dermatitis Caused by Wound Closure Tape Steri-Strip3M. Contact Dermatitis. 2025 Jul;93(1):68-70. doi: 10.1111/cod.14788. Epub 2025 Mar 20. No abstract available. | |
| 40821899 | Background | Hall JD, Schwartz E. Solving "T" Junction Wound Breakdown With a Single Tension-reducing Device. Plast Reconstr Surg Glob Open. 2025 Aug 15;13(8):e6882. doi: 10.1097/GOX.0000000000006882. eCollection 2025 Aug. |
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| ID | Term |
|---|---|
| D013530 | Surgical Wound Infection |
| D049291 | Seroma |
| ID | Term |
|---|---|
| D014946 | Wound Infection |
| D007239 | Infections |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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Participants will be assigned using 1:1 block randomization to one of two study arms. The intervention arm will receive Steri-Strip application following standard cesarean wound closure, while the control arm will receive standard wound closure alone. Participants will remain in their assigned group throughout the study, and outcomes will be assessed within 30 days postpartum.
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Neither participants nor treating clinicians will be blinded to treatment allocation because Steri-Strip application is readily visible following surgery.
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| Standard Cesarean Wound Closure | Procedure | Standard skin closure performed following cesarean delivery according to institutional practice. |
|
Hospital readmission attributable to wound infection, seroma, or wound separation/dehiscence following cesarean delivery.
| Within 30 days postpartum |
| Cost of Wound Management | Comparison of direct healthcare costs associated with wound closure materials and management of postoperative wound complications between study groups. | From cesarean delivery through 30 days postpartum |
| 40833607 | Background | Dominoni M, Torella M, Molitierno R, Fordellone M, Saccone G, Colacurci D, Lagana AS, Pano MR, Gardella B, La Verde M. Single-versus double-layer uterine closure at the time of cesarean delivery and risk of uterine scar niche: a systematic review and meta-analysis of randomized trials. Arch Gynecol Obstet. 2025 Oct;312(4):1095-1106. doi: 10.1007/s00404-025-08151-y. Epub 2025 Aug 20. |
| 15295247 | Background | Zempsky WT, Parrotti D, Grem C, Nichols J. Randomized controlled comparison of cosmetic outcomes of simple facial lacerations closed with Steri Strip Skin Closures or Dermabond tissue adhesive. Pediatr Emerg Care. 2004 Aug;20(8):519-24. doi: 10.1097/01.pec.0000136068.45198.ae. |
| 39234130 | Background | Sah N, Punga R, Kumar A, Shivhare P, Singh AK, Sah S, Shekhar A. The surgical outcome of sutureless skin closures using Octyl-2-cyanoacrylate (Dermabond) versus Steri-Strip. Natl J Maxillofac Surg. 2024 May-Aug;15(2):307-312. doi: 10.4103/njms.njms_102_22. Epub 2024 Jul 24. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D007249 | Inflammation |