LIFU for Chronic Pain and Generalized Anxiety Disorder

Accelerated Low-Intensity Focused Ultrasound (LIFU) for Chronic Pain and Generalized Anxiety Disorder: A Proof-of-Concept Case Series

A proof of concept case study to investigate accelerated LIFU protocol in chronic pain and anxiety populations.

A single-arm, open label, 2 cohort (chronic pain/GAD) case study with extended (6 months) follow-up following accelerated low-intensity focused ultrasound for neuromodulation.

Inclusion Criteria:

• GAD Symptoms - GAD-7 score >= 10, OASIS score >= 8, or PSWQ score >= 45. OR Chronic pain symptoms - moderate to severe pain, present for at least 3 months.

Exclusion Criteria:

• Claustrophobia
• Contraindications to MRI or CT
• Active medical disorder with CNS effects
• History of neurologic disorder
• History of head injury with LOC > 10 minutes
• Active drug or alcohol dependence