Precision Management of Urinary Tract Symptoms in Older Women: A Randomized Trial to Reduce Overtreatment
Precision Management of Urinary Tract Symptoms in Older Women: A Randomized Trial to Reduce Overtreatment
This project aims to improve the diagnosis and management of urinary tract symptoms in older women by comparing three common treatment strategies-empiric antibiotics, urinalysis-guided therapy, and culture-directed care-in a randomized trial. By integrating patient-reported outcomes, laboratory data, the study will identify which patients benefit from antibiotics and which can safely avoid them. Findings will inform precision care strategies and promote antibiotic stewardship while improving symptom outcomes and quality of life in this high-risk population.
Complete a 3-arm randomized pilot trial of either empiric, urinalysis-directed or culture-directed management for UTI symptoms in older women (≥age 65 years old) with a history of recurrent UTI. We will recruit and enroll 90 women with a history of rUTI from the University of Pittsburgh Medical Center - Women's Center for Bladder and Pelvic Health and the Pitt+Me® Research Registry. Once enrolled and randomized, women will be followed for a total of 28 days.
Inclusion Criteria:
Female biologic Sex
Age ≥65 years old
History of recurrent UTI per patient report of greater than 2 UTIs in the last 6 months or 3 UTIs in the last year
Patient reported UTI defined as:
Exclusion Criteria:
bradleym4@upmc.edu412-641-7850