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The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.
Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.
Implant success depends on several factors surgical and prosthetic factors (surgical technique and operator experience, timing and type of prosthetic loading and quality of pros-thetic rehabilitation), implant-related factors (material, design and surface), and patient-related factors (bone volume/quality at the recipient site and host response.
Despite the high success rate of dental implants, which is reported to be around 95%, failures due to lack of osseointegration remain a significant challenge Implant failures are classified according to the timing of the loss to Early Dental Implant Failure (EDIF) or late dental implant failure (LDIF). Early implant failure occurs due to improper implant placement and restoration, low bone volume or density, systemic conditions, or smoking.
Recent research has indicated that systemic health factors, particularly nutritional status, can significantly influence the process of osseointegration. Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone.
Vitamin D also exerts direct actions on bone (probably by regulating the expression of several bone growth factors). It controls mineral metabolism and the bone homeostasis by increasing calcium availability, by regulating PTH secretion, and by direct effects on bone formation and resorption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| supplemental group | Active Comparator | About 5 Participants will receive systemic vitamin D supplementation prior to and/or after dental implant placement. The purpose is to correct vitamin D deficiency and evaluate its effect on implant osseointegration and bone healing. |
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| Control Group | Active Comparator | About 5 Participants will not receive vitamin D supplementation. They will undergo standard dental implant placement and follow-up care without any intervention to correct vitamin D deficiency. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vit D | Drug | to address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Treatment of Dental Implant Osseointegration | Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery. | 3 Months |
| marginal bone loss after prosthesis placement | Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time. | six months after proshtesis placement |
| Measure | Description | Time Frame |
|---|---|---|
| Implant Survival Rate | Implant survival rate will be determined by the presence of the implant at the 6-month follow-up without any clinical or radiographic signs of failure, such as mobility, pain, infection, or significant bone loss. This outcome reflects the short-term success of the dental implant. | six months after prosthesis placement |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rana Mohamed Abu haiba, DSC | Contact | +201151306588 | rana.emam99@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Ahmed Kamal Abo Zekry, Professor | Oral & Maxillofacial Surgery, Future University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Future University in Egypt (FUE) | Recruiting | Cairo | New Cairo | 11511 | Egypt |
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| ID | Term |
|---|---|
| D014808 | Vitamin D Deficiency |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D015921 | Dental Implants |
| ID | Term |
|---|---|
| D003764 | Dental Materials |
| D001697 | Biomedical and Dental Materials |
| D017266 | Dental Prosthesis |
| D011476 | Prosthodontics |
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|
| D009750 |
| Nutritional and Metabolic Diseases |
| D003813 |
| Dentistry |
| D019736 | Prostheses and Implants |
| D004864 | Equipment and Supplies |
| D008420 | Manufactured Materials |
| D013676 | Technology, Industry, and Agriculture |