This study was planned on the basis of the hypothesis that 'food supplements containing collagen will support the clinical effectiveness of non-surgical periodontal therapy'. In this context, the aim of the study is to investigate the therapeutic efficacy of collagen-containing food supplement as a host modulation agent in the non-surgical periodontal treatment of individuals with stage 3-4 periodontitis in a clinical and biochemical manner in a comprehensive manner.

Initial day: Anamnesis, diagnosis and index measurements 2 days later, collection of serum samples from the patient, oral hygiene training and straightening of the whole mouth root surface and cleaning of the whole mouth tooth surface The next day, full mouth scalling and root planing are closed with the second session and tablets are started.

End of 2nd month:

Periodontal index measurement and oral hygiene training Collecting serum and tissue samples 2 days later

End of 6th month Periodontal index measurement and oral hygiene training Collecting serum and tissue samples 2 days later

Inclusion Criteria:

• 18 - 60 age
• stage 3-4 periodontitis

Exclusion Criteria:

• Patients who smoke more than 10 cigarettes a day
• Patients using immunosuppressive, oral contraceptive, bisphosphonate drugs
• Patients who are during pregnancy or lactation
• Having undergone periodontal treatment in the last 6 months, having used antibiotic anti-inflammatory medication in the last 4 weeks
• The presence of any autoimmune disease, osteoporotic disease or cancer disease
• Patients with renal and hepatic insufficiency
• Patients with thyroid dysfunction
• The presence of active infectious diseases(acute hepatitis, tuberculosis, AIDS)
• Chronic drug use affecting periodontal tissues(cyclosporine A, Phenytoin)
• Intake of antioxidant supplements

Data can be shared for appropriate reasons if requested.