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A single-center, prospective observational cohort study conducted at the University Hospital of Navarra. The primary objective is to expand knowledge of diverticular disease and its pathological variants, as well as the influence of the microbiota in our environment, both clinically and molecularly; to describe the clinical and pathological characteristics of patients with diverticulosis and acute diverticulitis; to analyze any differences in the microbiota; and to identify the risk factors and groups associated with diverticular disease in order to establish the best strategies for prevention and treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy patient | Patients identified in outpatient clinics for general and gastrointestinal surgery who have previously undergone a colonoscopy with no evidence of diverticulosis. | ||
| Patients with asymptomatic diverticulosis | Patients referred by the Endoscopy Unit of the Gastroenterology Department following the detection of diverticula during colonoscopy, with no clinical signs suggestive of diverticular disease. | ||
| Patients with a first episode of acute diverticulitis | Patients who present to the Emergency Department and are diagnosed with a first episode of acute diverticulitis of the left colon, confirmed by abdominal and pelvic CT scan, and who are evaluated and treated by the Department of General and Gastrointestinal Surgery. | ||
| Patients with recurrent acute diverticulitis | Patients previously included in the study following a first episode of acute diverticulitis who present with a documented recurrence during follow-up (2 years), and who are re-evaluated and treated in the Emergency Department by the Department of General and Digestive Surgery. |
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| Measure | Description | Time Frame |
|---|---|---|
| To investigate the microbiota influences the development of diverticulosis | To investigate whether the microbiota influences the development of diverticulosis and a first episode of acute diverticulitis. | From the diagnosis until two years |
| Measure | Description | Time Frame |
|---|---|---|
| To investigate how the microbiota affects the therapeutic response in patients presenting with a first episode of acute diverticulitis. | To investigate how the microbiota affects the therapeutic response in patients presenting with a first episode of acute diverticulitis. | From the diagnosis until 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Patients attended in outpatient clinics, the gastrointestinal endoscopy unit, and the emergency department at the University Hospital of Navarra
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitario de Navarra | Pamplona | Navarre | 310013 | Spain |
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| ID | Term |
|---|---|
| D043963 | Diverticulosis, Colonic |
| ID | Term |
|---|---|
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| To investigate how the microbiota is affected in patients treated with anti-inflammatory drugs versus antibiotic therapy. |
To investigate how the microbiota is affected in patients treated with anti-inflammatory drugs versus antibiotic therapy. |
| From the diagnosis until 8 weeks |
| To analyze the microbiota of patients who experience a recurrence of acute diverticulitis following a first episode compared to those who do not experience a recurrence within the first two years after the episode of acute diverticulitis. | To analyze the microbiota of patients who experience a recurrence of acute diverticulitis following a first episode compared to those who do not experience a recurrence within the first two years after the episode of acute diverticulitis. | From the diagnosis until 2 years |