The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation

The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation (CHEER4TTE)

CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.

Inclusion Criteria:

• Witnessed cardiac arrest
• Bystander CPR
• Refractory cardiac arrest (failure to achieve sustained ROSC >20 minutes)
• Initial cardiac rhythm VF, VT or PEA
• Within the hours of prehospital ECPR service operation

Exclusion Criteria:

• Initial cardiac rhythm asystole
• ROSC with sustained recovery
• Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest
• Evidence of/suspected end-stage disease:
• severe disability impairing activities of daily living
• end-stage organ disease - cardiac, liver, lung, renal
• other life-limiting diseases, e.g. malignancy, terminal illness
• advance health care directive
• Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19