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This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | Active Comparator | Surgical Depigmentation Alone |
|
| test I | Experimental | Surgical Depigmentation + CoQ10 |
|
| Test II | Experimental | Surgical Depigmentation + Vitamin C |
|
| Test III | Experimental | Surgical Depigmentation + CoQ10 + Vitamin C |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| surgical depigmentation | Procedure | Surgical gingival depigmentation performed using the conventional scalpel technique. The pigmented gingival epithelium is surgically removed under local anesthesia to eliminate melanin pigmentation and improve gingival esthetics. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in gingival pigmentation intensity using the Dummett Oral Pigmentation Index (DOPI). The DOPI scale from 0 to 3, where:0 = No clinical pigmentation ,1 = Mild pigmentation , 2 = Moderate pigmentation 3 = Heavy pigmentation | Change in gingival pigmentation intensity that measured by using a standardized gingival pigmentation index (DOPI) | 1 week, 1 month and 3 months. ,6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| nora abdelgawad associate professor, phd | Contact | +201019407891 | noramohamed.26@azhar.edu.eg | |
| nora abdelgawad abdelgawad, phd | Contact | 021019407891 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of dental medicine for girls? ALAZHAR University, Cairo, egypt | Recruiting | Nāşir | Egypt |
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Surgical gingival depigmentation performed using the conventional scalpel technique under local anesthesia. The pigmented gingival epithelium is surgically removed to eliminate physiologic melanin pigmentation and improve gingival esthetics. The procedure is performed as the standard treatment for gingival hyperpigmentation in all study participants.
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| Coenzyme Q10 | Dietary Supplement | Coenzyme Q10 administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation. |
|
| Vitamin C | Dietary Supplement | Vitamin C administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation. |
|
| Surgical Gingival Depigmentation Coenzyme Q10 Vitamin C | Dietary Supplement | Coenzyme Q10 and vitamin c administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival repigmentation. |
|
| ID | Term |
|---|---|
| D014820 | Vitiligo |
| ID | Term |
|---|---|
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C024989 | coenzyme Q10 |
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D006880 | Hydroxy Acids |
| D002241 | Carbohydrates |
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