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| Name | Class |
|---|---|
| Halic University | OTHER |
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This randomized controlled trial aims to evaluate the effects of a diet supplemented with curd cheese on anthropometric measurements, glycemia, and lipid profile in overweight adults. Participants aged 40-64 years with a BMI above 25 will be randomly assigned to an intervention group receiving 100 g of curd cheese at breakfast for 8 weeks or to a control group receiving a standard healthy diet without curd cheese. Primary outcomes include changes in fasting blood glucose and HbA1c, while secondary outcomes are changes in body composition, waist circumference, and lipid profile (HDL, LDL, triglycerides, total cholesterol).
Metabolic disorders, including obesity, dyslipidemia, and type 2 diabetes mellitus, are major public health concerns worldwide. Dietary protein quality and source have been shown to play important roles in regulating glucose and lipid metabolism. Whey-derived proteins are rich in branched-chain amino acids and bioactive peptides that may enhance insulin sensitivity, promote satiety, and improve lipid profiles.
Curd cheese (lor cheese) is a traditional dairy product obtained during whey processing, characterized by its high-quality protein, low fat content, and rich calcium composition. It represents an affordable and accessible food that could be incorporated into dietary interventions targeting metabolic health improvement.
This study aims to investigate the effects of a curd cheese-supplemented diet on anthropometric parameters, glycemic control (including fasting glucose and HbA1c), and lipid profile (total cholesterol, HDL, LDL, and triglycerides) in adults attending the Darıca Healthy Life Center. Participants will follow a controlled dietary intervention with or without curd cheese for eight weeks.
The hypothesis of this study is that regular consumption of curd cheese as part of a balanced diet may improve metabolic parameters through increased protein intake, better glycemic regulation, and enhanced lipid metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Curd Cheese Supplemented Diet Group | Experimental | Intervention Group - Arm Description: Participants in this arm follow a customized dietary plan for 8 weeks that includes daily servings of curd cheese. The diet is balanced for energy and macronutrient distribution according to individual needs. Curd cheese, as a high-quality protein and calcium source, is included to assess its specific effects on glucose and lipid parameters. This arm is designed to evaluate the unique metabolic effects of curd cheese supplementation compared to the control group. |
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| Standard Diet Group | No Intervention | Participants in this arm follow a standard dietary plan for 8 weeks without curd cheese. The diet is balanced according to individual energy and macronutrient needs. This arm serves as a comparison group to determine the specific effects of curd cheese supplementation observed in the intervention group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Curd Cheese Supplemented Diet | Dietary Supplement | This intervention consists of daily consumption of 100 grams of curd cheese as part of a personalized dietary plan for 8 weeks. Curd cheese is consumed at breakfast and integrated into the participants' regular meal plans. The diet is balanced for total energy and macronutrient distribution according to individual nutritional needs. All participants in this arm receive the same type and brand of curd cheese throughout the intervention period. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in HbA1c Levels | To evaluate the effect of a curd cheese-supplemented diet on glycemic control by assessing changes in HbA1c levels from baseline to the end of the 8-week intervention. | Baseline and after 8 weeks of intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Fasting Glucose | To assess short-term glycemic response by measuring fasting blood glucose at baseline and after the 8-week intervention. | Baseline and after 8 weeks |
| Change in Lipid Profile |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ahmet M GÜNAL, PhD, RD | Haliç University | Principal Investigator |
| Salim YILMAZ, PhD | Acıbadem Mehmet Ali Aydınlar University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Darıca Healthy Life Center | Kocaeli | DARICA | 41700 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27197855 | Background | Kataoka Y, Kamijo YI, Ogawa Y, Sumiyoshi E, Nakae M, Ikegawa S, Manabe K, Morikawa M, Nagata M, Takasugi S, Masuki S, Nose H. Effects of hypervolemia by protein and glucose supplementation during aerobic training on thermal and arterial pressure regulations in hypertensive older men. J Appl Physiol (1985). 2016 Oct 1;121(4):1021-1031. doi: 10.1152/japplphysiol.00033.2016. Epub 2016 May 19. | |
| 34120735 |
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Individual participant data (IPD) will not be shared outside the research team to ensure participant privacy and confidentiality.
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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This is a parallel-group, randomized controlled trial. Participants are randomly assigned to either the intervention group, receiving a dietary plan supplemented with curd cheese, or the control group, receiving a standard dietary plan without curd cheese. Both groups are followed for 8 weeks to assess changes in glucose and lipid parameters. The study is open-label; participants and investigators are aware of group assignments.
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This study is open-label; there is no masking. Both participants and investigators are aware of group assignments.
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To evaluate the effect of curd cheese supplementation on lipid metabolism by assessing changes in total cholesterol, LDL, HDL, and triglycerides from baseline to the end of the intervention.
| Baseline and after 8 weeks |
| Change in Anthropometric Measures | To evaluate changes in body mass index (BMI) from the start to the end of the intervention. | Baseline and after 8 weeks |
| Change in Anthropometric Measures | To assess changes in body weight from baseline to the end of the intervention. | Baseline and after 8 weeks |
| Change in Anthropometric Measures | To evaluate changes in body fat percentage from the beginning to the end of the intervention. | Baseline and after 8 weeks |
| Change in Anthropometric Measures | To assess changes in waist circumference from the beginning to the end of the intervention. | Baseline and after 8 weeks |
| Background |
| Vogtschmidt YD, Raben A, Faber I, de Wilde C, Lovegrove JA, Givens DI, Pfeiffer AFH, Soedamah-Muthu SS. Is protein the forgotten ingredient: Effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. Atherosclerosis. 2021 Jul;328:124-135. doi: 10.1016/j.atherosclerosis.2021.05.011. Epub 2021 May 26. |
| 37328108 | Background | Zhang M, Dong X, Huang Z, Li X, Zhao Y, Wang Y, Zhu H, Fang A, Giovannucci EL. Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies. Adv Nutr. 2023 Sep;14(5):1170-1186. doi: 10.1016/j.advnut.2023.06.007. Epub 2023 Jun 15. |
| 25005331 | Background | Jakubowicz D, Froy O, Ahren B, Boaz M, Landau Z, Bar-Dayan Y, Ganz T, Barnea M, Wainstein J. Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial. Diabetologia. 2014 Sep;57(9):1807-11. doi: 10.1007/s00125-014-3305-x. Epub 2014 Jul 10. |