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This study investigated whether the shape of the face affects how jaw muscles respond to botulinum toxin injections in people who grind their teeth (bruxism). Participants were divided into two groups based on their facial structure: low-angle (shorter face height) and normal-angle. Each participant received botulinum toxin type A injections into the masseter (jaw) muscle. Bite force measurements were taken before and 15 days after the injection using the T-Scan computerized occlusal analysis system. The study aimed to determine whether facial structure influences the early changes in bite force balance following the injection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Masseter BTX-A Injection (Low-Angle and Normal-Angle Subgroups) | Experimental | Patients with bruxism received bilateral masseter muscle injections of 25 units of botulinum toxin type A (Botox®, Allergan) per side. T-Scan occlusal force measurements were performed at baseline (T0) and day 15 post-injection (T1). Participants were stratified into low-angle and normal-angle subgroups based on GoGn/SN cephalometric angle. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Botulinum Toxin Type A (BOTOX) Injection | Biological | Botulinum toxin type A (Botox®, Allergan, Irvine, CA, USA) was injected bilaterally into the masseter muscle at a dose of 25 units per side (50 units total per patient). Injections were performed by a single experienced clinician under sterile conditions using a 30-gauge needle. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Center of Force (CoF) | The Center of Force (CoF) represents the geometric center of the total occlusal force distribution, measured using the T-Scan Novus™ computerized occlusal analysis system (version 10.0.40; Tekscan, Inc., South Boston, MA, USA). CoF values closer to zero indicate greater bilateral occlusal balance. Within-group changes (T0 to T1) and between-group differences were assessed and compared between low-angle (GoGn/SN < 26°) and normal-angle (GoGn/SN 26-38°) subgroups. | Baseline (T0) and day 15 post-injection (T1) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Anterior and Posterior Force Percentage | Anterior force percentage is defined as the combined occlusal force distribution of the anterior teeth, and posterior force percentage as the combined force distribution of the posterior teeth. Both were measured using the T-Scan Novusâ„¢ system at baseline (T0) and day 15 post-injection (T1). Within-group changes and between-group differences in anterior-posterior force distribution were evaluated and compared between low-angle and normal-angle subgroups. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Esra AgaoÄŸlu Mogul | Department of Orthodontics, Faculty of Dentistry, Biruni University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Orthodontics, Faculty of Dentistry, Biruni University | Istanbul | Istanbul | 34010 | Turkey (Türkiye) |
Individual participant data will not be shared due to patient privacy and ethical restrictions. Data are available from the corresponding author on reasonable request.
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| ID | Term |
|---|---|
| D002012 | Bruxism |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D006184 | Habits |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D019274 | Botulinum Toxins, Type A |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
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|
|
| Baseline (T0) and day 15 post-injection (T1) |
| D006867 |
| Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |