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| Name | Class |
|---|---|
| The Second Affiliated Hospital of Hainan Medical University | OTHER |
| Beijing Anzhen Hospital | OTHER |
| West China Hospital | OTHER |
| Xiangya Hospital of Central South University |
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A multicenter observational study on pregnancy-related aortic dissection
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AD occurred during pregnancy, labor, and puerperium attributable to pregnancy- related conditions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intervention strategies including medication or surgery | Other | Medication or surgery (delivery or surgery first, or single-stage delivery and surgery) is determined based on gestational age and the type of AD, and also in consideration of the decisions made by the patient and their relatives. |
| Measure | Description | Time Frame |
|---|---|---|
| Early-term mortality of mothers and fetuses (or newborns) | All-cause mortality within 30 days after treatment. | Death within 30 days after treatment. |
| Long-term mortality of mothers and children | All-cause mortality during the follow-up period. | Through study completion, an average of 3 years. |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of maternal adverse events | The reinterventions for mothers due to aortic and obstetric conditions. | Through study completion, an average of 3 years. |
| The incidence of neonatal developmental abnormalities |
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Inclusion Criteria:
Exclusion Criteria:
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Women who sustained aortic dissection that occurred during pregnancy, labor, or within 12 weeks postpartum
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Anzhen Hospital, Tongzhou | Beijing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27825688 | Background | Zhu JM, Ma WG, Peterss S, Wang LF, Qiao ZY, Ziganshin BA, Zheng J, Liu YM, Elefteriades JA, Sun LZ. Aortic Dissection in Pregnancy: Management Strategy and Outcomes. Ann Thorac Surg. 2017 Apr;103(4):1199-1206. doi: 10.1016/j.athoracsur.2016.08.089. Epub 2016 Nov 5. | |
| 32259204 | Background | Ma WG, Zhu JM, Chen Y, Qiao ZY, Ge YP, Li CN, Zheng J, Liu YM, Sun LZ. Aortic dissection during pregnancy and postpartum in patients with Marfan syndrome: a 21-year clinical experience in 30 patients. Eur J Cardiothorac Surg. 2020 Aug 1;58(2):294-301. doi: 10.1093/ejcts/ezaa048. |
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| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D000784 | Aortic Dissection |
| D008382 | Marfan Syndrome |
| D055947 | Loeys-Dietz Syndrome |
| D000094623 | Ehlers-Danlos Syndrome, Type IV |
| ID | Term |
|---|---|
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000094665 | Dissection, Blood Vessel |
| D000783 | Aneurysm |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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| OTHER |
| Second Xiangya Hospital of Central South University | OTHER |
| Sichuan Provincial People's Hospital | OTHER |
| Yantai Yuhuangding Hospital | OTHER |
| First Hospital of China Medical University | OTHER |
| First Affiliated Hospital Xi'an Jiaotong University | OTHER |
| Qinghai Red Cross Hospital | OTHER |
| Shanxi Bethune Hospital | OTHER |
| Shandong Provincial Hospital | OTHER_GOV |
| Shengjing Hospital | OTHER |
| Zhejiang Provincial People's Hospital | OTHER |
| Ningbo Medical Center Lihuili Hospital | OTHER_GOV |
| Central China Fuwai Hospital of Zhengzhou University | OTHER |
| Xiamen Cardiovascular Hospital, Xiamen University | OTHER |
| The Central Hospital of Linfen | UNKNOWN |
| Shenzhen Sun Yat-sen Cardiovascular Hospital | OTHER |
| The Affiliated Hospital Of Guizhou Medical University | OTHER |
| The University of Hong Kong-Shenzhen Hospital | OTHER |
| Hebei Medical University Fourth Hospital | OTHER |
| Second Affiliated Hospital of Nanchang University | OTHER |
| Southwest Hospital, China | OTHER |
| Gulou Hospital Affiliated to Medical College of Nanjing University | UNKNOWN |
| The Second Hospital of Shandong University | OTHER |
| First Affiliated Hospital, Sun Yat-Sen University | OTHER |
| First Affiliated Hospital of Gannan Medical University | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Lanzhou University First Hospital | UNKNOWN |
| Peking Union Medical College Hospital | OTHER |
| First Affiliated Hospital of Harbin Medical University | OTHER |
| The First Hospital of Jilin University | OTHER |
| The Fourth Affiliated Hospital of Zhejiang University School of Medicine | OTHER |
| RenJi Hospital | OTHER |
| Peking University People's Hospital | OTHER |
| The First Affiliated Hospital of Guangzhou Medical University | OTHER |
| Henan Provincial Chest Hospital | OTHER |
| First Affiliated Hospital of Wenzhou Medical University | OTHER |
| Shanghai Zhongshan Hospital | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| The First Affiliated Hospital of Bengbu Medical University | OTHER |
| Wannan Medical College Yijishan Hospital | OTHER |
| Anhui Provincial Hospital | OTHER_GOV |
| Shanxi Yuncheng Central Hospital | UNKNOWN |
| Liuzhou Workers' Hospital | OTHER_GOV |
| The Third People's Hospital of Chengdu | OTHER |
| Suining Central Hospital | OTHER |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | OTHER |
| Wuhan TongJi Hospital | OTHER |
| Renmin Hospital of Wuhan University | OTHER |
| The General Hospital of Southern Theater Command | OTHER |
| Xijing Hospital，FMMU | UNKNOWN |
| Zunyi Medical College | OTHER |
| The Affiliated Hospital of Qingdao University | OTHER |
| Shanghai Chest Hospital of Shanghai Jiao Tong University | OTHER |
| The First Affiliated Hospital of Anhui Medical University | OTHER |
| The People's Hospital of Gaozhou | OTHER |
| The Second Hospital of Nanjing Medical University | OTHER |
| Nanjing First Hospital, Nanjing Medical University | OTHER |
| General Hospital of Ningxia Medical University | OTHER |
| Guangdong Provincial People's Hospital | OTHER |
| Yan'an Affiliated Hospital of Kunming Medical University | OTHER |
| Second Affiliated Hospital of Zhengzhou University | OTHER |
| Henan Provincial People's Hospital | OTHER |
| Wuhan Asia Heart Hospital | OTHER |
| Changhai Hospital | OTHER |
| Taihe Hospital affiliated to Hubei University of Medicine | UNKNOWN |
| Zhongnan Hospital | OTHER |
| Luoyang Central Hospital | OTHER |
| People's Hospital of Xinjiang Uygur Autonomous Region | OTHER |
| Qingdao Municipal Hospital | OTHER |
| The First Affiliated Hospital of Nanchang University | OTHER |
| Hainan General Hospital | OTHER |
| The First Hospital of Hebei Medical University | OTHER |
| Gansu Provincial Hospital | OTHER |
| The First Affiliated Hospital of Shanxi Medical University | OTHER |
| First Affiliated Hospital of Guangxi Medical University | OTHER |
| First Affiliated Hospital of Ningbo University | NETWORK |
| Fujian Medical University Union Hospital | OTHER |
| Huai'an First People's Hospital | OTHER |
| Chinese University of Hong Kong | OTHER |
| Yichang Central People's Hospital | OTHER |
| Zhongshan People's Hospital, Guangdong, China | OTHER |
| Shiyan City Renmin Hospital | OTHER_GOV |
| The First Affiliated Hospital of Dalian Medical University | OTHER |
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|
Adverse events occurring in newborns during follow-up, including suspected signs of heritable aortic disease and growth and developmental abnormalities (cerebral palsy, intellectual disabilities, etc.)
| Through study completion, an average of 3 years. |
| 41520724 | Background | Zhu JM, Chen SW, Ma WG, Chen Y, Qiao ZY, Hu HO, Li CN, Zhang J, Sun LZ. Type A aortic dissection during pregnancy and postpartum: Experience in 60 patients over 25 years. J Thorac Cardiovasc Surg. 2026 Jun;171(6):1186-1197.e1. doi: 10.1016/j.jtcvs.2025.12.030. Epub 2026 Jan 9. |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000094683 | Acute Aortic Syndrome |
| D001018 | Aortic Diseases |
| D001848 | Bone Diseases, Developmental |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D006331 | Heart Diseases |
| D000015 | Abnormalities, Multiple |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D019465 | Craniofacial Abnormalities |
| D009139 | Musculoskeletal Abnormalities |
| D001014 | Aortic Aneurysm |
| D004535 | Ehlers-Danlos Syndrome |
| D020141 | Hemostatic Disorders |
| D006474 | Hemorrhagic Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D012868 | Skin Abnormalities |
| D012873 | Skin Diseases, Genetic |
| D003095 | Collagen Diseases |
| D012871 | Skin Diseases |