Newly graduated nurses often experience high levels of psychological stress, sleep disturbance, fatigue, and burnout during the early transition into clinical practice. Early identification of burnout and retention risk may help improve mental well-being, workforce stability, and quality of patient care.

This longitudinal observational study aims to develop a non-invasive sleep-based prediction platform for assessing burnout and retention risk among postgraduate nurses. Participants will undergo repeated psychological assessments and non-contact sleep monitoring during the study period. Sleep-related physiological parameters, including sleep efficiency, sleep structure, heart rate variability, and respiratory variability, will be collected together with validated psychological questionnaires.

The study will further apply machine learning and artificial intelligence approaches to integrate longitudinal physiological and psychological data for risk prediction and early identification of burnout-related conditions. The findings may support future development of precision mental health monitoring and supportive management strategies for high-stress healthcare workers.

Postgraduate nurses frequently experience substantial psychological and physiological stress during the transition from academic training to clinical practice. Heavy workloads, rotating shifts, emotional demands, and adaptation to clinical environments may contribute to sleep disturbance, fatigue, burnout, and increased turnover intention. Previous studies have demonstrated significant associations between sleep quality, autonomic nervous system regulation, emotional distress, and occupational burnout among healthcare workers, particularly in shift-working nurses.

Current psychological assessments mainly rely on self-reported questionnaires and short-term evaluations, which may not adequately capture dynamic physiological changes over time. Recent advances in non-contact sleep monitoring technologies provide opportunities for continuous and low-burden collection of sleep-related physiological data in natural sleep environments. In addition, artificial intelligence and machine learning approaches may improve early identification of individuals at higher risk of burnout and retention problems.

This study is a prospective longitudinal observational study designed to investigate the relationship between sleep-related physiological characteristics, psychological status, burnout risk, and retention risk among postgraduate nurses during the early clinical transition period.

Eligible participants will include newly employed postgraduate nurses within three months of clinical employment. Participants will complete validated psychological questionnaires, including the Brief Symptom Rating Scale-5 (BSRS-5), Chinese Health Questionnaire-12 (CHQ-12), Pittsburgh Sleep Quality Index (PSQI), Karolinska Sleepiness Scale (KSS), and Copenhagen Burnout Inventory (CBI). In parallel, participants will undergo non-invasive and non-contact sleep monitoring under natural sleep conditions. Sleep-related physiological parameters including sleep efficiency, sleep stage distribution, deep sleep proportion, REM sleep stability, heart rate variability, and respiratory variability will be analyzed.

Repeated assessments will be conducted longitudinally at baseline, 3 months, and 6 months. Statistical analyses will include descriptive statistics, longitudinal analyses, generalized estimating equations, mixed-effects models, and survival-related analyses when applicable. Machine learning and deep learning approaches, including Random Forest, XGBoost, and longitudinal prediction models, will be applied to develop predictive models for burnout and retention risk.

The study does not involve therapeutic intervention, medication administration, or changes to work schedules. All collected data will be de-identified and managed according to institutional research ethics and privacy protection regulations. The results of this study may contribute to the future development of precision mental health monitoring systems and supportive management strategies for high-stress healthcare professionals.

Inclusion Criteria:

• Newly employed postgraduate nurses within the first 3 months of clinical practice
• Age 20 to 65 years
• Full-time clinical nursing staff
• Able to read and complete Chinese questionnaires
• Willing to participate in repeated psychological assessments and non-invasive sleep monitoring
• Able to provide written informed consent

Exclusion Criteria:

• Diagnosed severe sleep disorders
• Diagnosed severe psychiatric disorders
• Current use of medications that significantly affect sleep or autonomic nervous system function
• Inability to comply with longitudinal follow-up procedures
• Inability to complete repeated sleep monitoring assessments

The study population consists of newly employed postgraduate nurses during the early clinical transition period at a medical center in Taiwan. Participants will be followed longitudinally to evaluate sleep-related physiological characteristics, psychological stress, burnout risk, and retention risk using repeated questionnaires and non-invasive sleep monitoring.

No individual participant data (IPD) will be shared because the study involves sensitive psychological and physiological data collected from healthcare workers, and data sharing is restricted to protect participant privacy and confidentiality in accordance with institutional research ethics regulations.