CoSMAP Trial: SP-EA vs MP-TA Robot-Assisted Radical Prostatectomy

Comparison of Perioperative and Postoperative Outcomes of Single-port (SP) Extraperitoneal Approach and Multi-port (MP) Transperitoneal Approach in Robot-assisted Radical Prostatectomy：A Propensity Score-matched Retrospective Cohort Study

This multicenter retrospective observational study aims to compare perioperative and postoperative outcomes between the da Vinci SP extraperitoneal approach (SP-EA) and the robotic multi-port transperitoneal approach (MP-TA) in robot-assisted radical prostatectomy for localized prostate cancer.

This is a multicenter, retrospective, propensity score-matched observational cohort study conducted in Japan.

The study aims to compare perioperative and postoperative outcomes of robot-assisted radical prostatectomy (RARP) performed using the da Vinci SP extraperitoneal approach (SP-EA) and the robotic multi-port transperitoneal approach (MP-TA) in patients with localized prostate cancer.

Clinical data will be retrospectively and continuously collected from participating institutions and analyzed to evaluate the utility and potential clinical benefits of the SP-EA approach.

Inclusion Criteria:

1. Patients with localized prostate cancer (clinical stage T1-T3a, N0, M0) eligible for radical prostatectomy
2. Patients who underwent RARP via SP-EA or MP-TA on or after January 1, 2023
3. Patients with available postoperative follow-up data for ≥6 months (≥166 days) *note 1)

Exclusion Criteria:

1. Patients who have expressed an intention to refuse the use of their data for this study
2. Patients who underwent RARP using surgical approaches other than those specified in the inclusion criteria (e.g., transvesical approach)
3. Patients who underwent RARP with pelvic lymph node dissection (PLND)
4. Patients with a history of radiotherapy for prostate cancer
5. Any other patients whom the principal investigator or a co-investigator deem inappropriate, such as those with missing outcome data.