Patients with vascular and metabolic transfemoral amputations experience substantial functional limitations and high rates of prosthetic abandonment. Although multidisciplinary inpatient rehabilitation programs have been associated with improved outcomes, evidence regarding their effectiveness in low- and middle-income countries remains limited.

This study aims to evaluate the effectiveness of an inpatient rehabilitation and prosthetic training model implemented at the National Institute of Rehabilitation "Luis Guillermo Ibarra Ibarra" (INRLGII), Mexico. An ambispective cohort design will be used, including a retrospective review of patients treated between 2013 and 2025 and a prospective cohort enrolled between 2026 and 2029.

The primary objective is to determine the proportion of patients who achieve functional prosthesis use after hospital discharge. Secondary objectives include identifying clinical, metabolic, functional, and psychosocial factors associated with successful prosthetic use, adherence, and abandonment.

Background

Diabetes mellitus and peripheral vascular disease are major causes of lower-limb amputation worldwide. Transfemoral amputation is associated with substantial disability, increased energy expenditure during ambulation, reduced mobility, and decreased quality of life. Despite advances in prosthetic technology, long-term prosthetic use remains challenging, with reported abandonment rates ranging from 30% to 60%.

The National Institute of Rehabilitation "Luis Guillermo Ibarra Ibarra" (INRLGII) has developed a multidisciplinary inpatient rehabilitation and prosthetic training model for patients with vascular and metabolic amputations. The program integrates rehabilitacion medicine, physical therapy, occupational therapy, psychology, cardiopulmonary evaluation, biomedical engineering, and prosthetic fabrication in a coordinated inpatient setting.

Although international evidence suggests that inpatient multidisciplinary rehabilitation improves functional outcomes and prosthetic success, no institutional or national studies have systematically evaluated the effectiveness of this model in Mexican patients with vascular and metabolic transfemoral amputation.

Objective

To evaluate the effectiveness of an inpatient multidisciplinary rehabilitation and prosthetic training model in patients with unilateral transfemoral amputation of vascular or metabolic etiology.

Study Design

This is an observational, longitudinal, ambispective cohort study.

The retrospective phase will include patients treated between 2013 and 2025 through review of electronic medical records.

The prospective phase will include consecutive patients enrolled between 2026 and 2029. Functional prosthesis use will be assessed at 3 and 6 months after discharge using the Houghton Scale and structured recording of daily prosthesis use.

Hypothesis

The inpatient rehabilitation and prosthetic training model is associated with a higher proportion of functional prosthesis use at 6 months compared with rates reported in the international literature for vascular and metabolic transfemoral amputees

Inclusion Criteria:

• Unilateral transfemoral amputation secondary to vascular disease or diabetes-related complications.
• Participation in the INRLGII inpatient prosthetic rehabilitation program.
• Availability of complete clinical records or willingness to participate in follow-up assessments .
• Signed informed consent.

Exclusion Criteria:

• Current prosthesis user before admission to the INRLGII rehabilitation program.
• Bilateral major lower-limb amputation.
• Inability to complete follow-up assessments.

Withdrawal Criteria

• Incomplete or inconsistent clinical information.
• Loss to follow-up during the 6-month observation period.
• Participant withdrawal of consent.

Adult patients (≥18 years) with unilateral transfemoral amputation secondary to vascular disease or diabetes-related complications who are treated through the inpatient prosthetic rehabilitation program at the National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra (INRLGII), Mexico.

Individual participant data will not be shared because the dataset contains sensitive clinical information from a relatively small patient population, which may increase the risk of participant re-identification despite de-identification procedures. Data will be used exclusively for the purposes approved by the institutional ethics and research committees.