DEPART Study at Yale

Dupuytren's Disease Evaluation of Preventative or Adjuvant Radiation Therapy: DEPART

This is a randomized study to determine whether radiation therapy reduces the risk of progression / recurrence of Dupuytren's disease / contracture.

Inclusion Criteria:

• English-speaking
• Patient consent
• No previous radiotherapy to the affected hand
• No history of radiation sensitivity diseases (e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni)
• Age>30
• Life expectancy >5 years
• Available and willing to participate in at least 5 years of follow-up
• Female patients capable of child-bearing that are not pregnant

Exclusion Criteria:

• Pregnancy or lactation
• Known genetic disease that would make them extremely sensitive to radiation therapy, e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni